HTLV-1-associated infective dermatitis demonstrates low frequency of

Li Ning Tapia, Elsa Ml; Torres-Cabala, Carlos A.; Bravo Puccio, Francisco Gerardo; Miranda, Roberto N.; Prieto, Victor G.; Curry, Jonathan L.; Ramos, Cesar; Tetzlaff, Michael T.

dc.contributor.author	Torres-Cabala, Carlos A.
dc.contributor.author	Curry, Jonathan L.
dc.contributor.author	Li Ning Tapia, Elsa Ml
dc.contributor.author	Ramos, Cesar
dc.contributor.author	Tetzlaff, Michael T.
dc.contributor.author	Prieto, Victor G.
dc.contributor.author	Miranda, Roberto N.
dc.contributor.author	Bravo Puccio, Francisco Gerardo
dc.date.accessioned	2019-02-06T14:52:39Z
dc.date.available	2019-02-06T14:52:39Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5345
dc.description.abstract	Background. Human T-lymphotropic virus (HTLV)-1-associated infective dermatitis (ID) is a rare severe chronic eczema, considered as a harbinger for the development of cutaneous adult T-cell leukemia/lymphoma (ATLL) and/or HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The pathogenesis of ID remains unclear. High numbers of peripheral blood CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) have been reported in ATLL and HAM/TSP. Objective. To investigate the status of Tregs, unknown to date, and the histopathological features of ID. Methods. We studied 16 skin biopsies from 15 Peruvian adults and children with ID by immunohistochemistry. Results. Histopathological patterns were seborrheic dermatitis-like and lichenoid. Intraepidermal lymphocytes were conspicuous. The infiltrate was composed of a CD3+ T cell infiltrate with a predominance of CD8+ over CD4+ cells. CD4+ CD25+ FoxP3+ Tregs were rare and their numbers were significantly lower than those reported in other inflammatory dermatoses. Conclusion. Tregs have an essential role in maintaining immune homeostasis of skin. Treg dysregulation ends in severe clinical manifestations. The clinical presentation of ID, with lesions resembling those seen in patients with atopic dermatitis and with mutations in the FoxP3 gene, is in agreement with a common Treg-deficient skin environment in these disorders, possibly secondary to HTLV-1 infection.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Journal of Dermatological Science
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Immunohistochemistry	en_US
dc.subject	Adolescent	en_US
dc.subject	Adult	en_US
dc.subject	Female	en_US
dc.subject	Humans	en_US
dc.subject	Male	en_US
dc.subject	Young Adult	en_US
dc.subject	Child	en_US
dc.subject	Child, Preschool	en_US
dc.subject	Chronic Disease	en_US
dc.subject	Aged	en_US
dc.subject	Aged, 80 and over	en_US
dc.subject	Middle Aged	en_US
dc.subject	Human T-lymphotropic virus 1	en_US
dc.subject	CD3 Complex/analysis	en_US
dc.subject	CD4-CD8 Ratio	en_US
dc.subject	Eczema/immunology/pathology/virology	en_US
dc.subject	Forkhead Transcription Factors/analysis	en_US
dc.subject	FoxP3	en_US
dc.subject	Histopathology	en_US
dc.subject	HTLV-1	en_US
dc.subject	HTLV-I Infections/immunology/pathology	en_US
dc.subject	Infective dermatitis	en_US
dc.subject	Skin Diseases, Viral/immunology/pathology	en_US
dc.subject	T-Lymphocytes, Regulatory/chemistry	en_US
dc.subject	Tregs	en_US
dc.title	HTLV-1-associated infective dermatitis demonstrates low frequency of	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.jdermsci.2015.01.003
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.15
dc.relation.issn	1873-569X