Universidad Peruana Cayetano Heredia

HTLV-1-associated infective dermatitis demonstrates low frequency of

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dc.contributor.author Torres-Cabala, Carlos A.
dc.contributor.author Curry, Jonathan L.
dc.contributor.author Li Ning Tapia, Elsa Ml
dc.contributor.author Ramos, Cesar
dc.contributor.author Tetzlaff, Michael T.
dc.contributor.author Prieto, Victor G.
dc.contributor.author Miranda, Roberto N.
dc.contributor.author Bravo Puccio, Francisco Gerardo
dc.date.accessioned 2019-02-06T14:52:39Z
dc.date.available 2019-02-06T14:52:39Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5345
dc.description.abstract Background. Human T-lymphotropic virus (HTLV)-1-associated infective dermatitis (ID) is a rare severe chronic eczema, considered as a harbinger for the development of cutaneous adult T-cell leukemia/lymphoma (ATLL) and/or HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The pathogenesis of ID remains unclear. High numbers of peripheral blood CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) have been reported in ATLL and HAM/TSP. Objective. To investigate the status of Tregs, unknown to date, and the histopathological features of ID. Methods. We studied 16 skin biopsies from 15 Peruvian adults and children with ID by immunohistochemistry. Results. Histopathological patterns were seborrheic dermatitis-like and lichenoid. Intraepidermal lymphocytes were conspicuous. The infiltrate was composed of a CD3+ T cell infiltrate with a predominance of CD8+ over CD4+ cells. CD4+ CD25+ FoxP3+ Tregs were rare and their numbers were significantly lower than those reported in other inflammatory dermatoses. Conclusion. Tregs have an essential role in maintaining immune homeostasis of skin. Treg dysregulation ends in severe clinical manifestations. The clinical presentation of ID, with lesions resembling those seen in patients with atopic dermatitis and with mutations in the FoxP3 gene, is in agreement with a common Treg-deficient skin environment in these disorders, possibly secondary to HTLV-1 infection. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Dermatological Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Immunohistochemistry en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Chronic Disease en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Middle Aged en_US
dc.subject Human T-lymphotropic virus 1 en_US
dc.subject CD3 Complex/analysis en_US
dc.subject CD4-CD8 Ratio en_US
dc.subject Eczema/immunology/pathology/virology en_US
dc.subject Forkhead Transcription Factors/analysis en_US
dc.subject FoxP3 en_US
dc.subject Histopathology en_US
dc.subject HTLV-1 en_US
dc.subject HTLV-I Infections/immunology/pathology en_US
dc.subject Infective dermatitis en_US
dc.subject Skin Diseases, Viral/immunology/pathology en_US
dc.subject T-Lymphocytes, Regulatory/chemistry en_US
dc.subject Tregs en_US
dc.title HTLV-1-associated infective dermatitis demonstrates low frequency of en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jdermsci.2015.01.003
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.15
dc.relation.issn 1873-569X


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