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Automatic Generation of Validated Specific Epitope Sets

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dc.contributor.author Carrasco Pro, Sebastian
dc.contributor.author Sidney, John
dc.contributor.author Paul, Sinu
dc.contributor.author Lindestam Arlehamn, Cecilia
dc.contributor.author Weiskopf, Daniela
dc.contributor.author Peters, Bjoern
dc.contributor.author Sette, Alessandro
dc.date.accessioned 2019-02-06T14:52:40Z
dc.date.available 2019-02-06T14:52:40Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5352
dc.description.abstract Accurate measurement of B and T cell responses is a valuable tool to study autoimmunity, allergies, immunity to pathogens, and host-pathogen interactions and assist in the design and evaluation of T cell vaccines and immunotherapies. In this context, it is desirable to elucidate a method to select validated reference sets of epitopes to allow detection of T and B cells. However, the ever-growing information contained in the Immune Epitope Database (IEDB) and the differences in quality and subjects studied between epitope assays make this task complicated. In this study, we develop a novel method to automatically select reference epitope sets according to a categorization system employed by the IEDB. From the sets generated, three epitope sets (EBV, mycobacteria and dengue) were experimentally validated by detection of T cell reactivity ex vivo from human donors. Furthermore, a web application that will potentially be implemented in the IEDB was created to allow users the capacity to generate customized epitope sets. en_US
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartofseries Journal of Immunology Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Immunologic Tests en_US
dc.subject Cells, Cultured en_US
dc.subject Immunotherapy en_US
dc.subject Databases, Factual en_US
dc.subject Dengue Virus/immunology en_US
dc.subject Electronic Data Processing en_US
dc.subject Epitope Mapping/methods en_US
dc.subject Epitopes, T-Lymphocyte/metabolism en_US
dc.subject Herpesvirus 4, Human/immunology en_US
dc.subject Lymphocyte Activation en_US
dc.subject Mycobacteriaceae/immunology en_US
dc.subject Precision Medicine en_US
dc.subject Software en_US
dc.subject T-Lymphocytes/immunology en_US
dc.subject Viral Proteins/immunology en_US
dc.title Automatic Generation of Validated Specific Epitope Sets en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1155/2015/763461
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 2314-7156


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