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Immunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma

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dc.contributor.author de Souza do Nascimento, Juliana
dc.contributor.author Carlos, Roman
dc.contributor.author Delgado-Azanero, Wilson
dc.contributor.author Mosqueda Taylor, Adalberto
dc.contributor.author de Almeida, Oslei Paes
dc.contributor.author Romanach, Mario Jose
dc.contributor.author de Andrade, Bruno Augusto Benevenuto
dc.date.accessioned 2019-02-06T14:52:40Z
dc.date.available 2019-02-06T14:52:40Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5354
dc.description.abstract BACKGROUND: Cyclooxygenase-2 (COX-2) catalyses the conversion of arachidonic acid to prostaglandin, and its overexpression has been demonstrated in different malignant tumors, including cutaneous melanoma. However, no data about the expression of this protein in oral melanocytic lesions are available to date. The aim of this study was to evaluate the immunohistochemical expression of COX-2 in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. METHODS: COX-2 was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 36 intramucosal nevi and 13 primary oral melanomas, and in four cutaneous nevi and eight melanomas. RESULTS: All cases of oral and cutaneous melanomas were positive for COX-2. On the other hand, all oral and cutaneous melanocytic nevi were negative. CONCLUSION: COX-2 is highly positive in oral melanomas and negative in oral nevi and might represent a useful marker to distinguish melanocytic lesions of the oral cavity. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof urn:issn:1600-0714
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Immunohistochemistry en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Young Adult en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Middle Aged en_US
dc.subject Biomarkers, Tumor/biosynthesis en_US
dc.subject cutaneous melanocytic nevi en_US
dc.subject cutaneous melanoma en_US
dc.subject Cyclooxygenase 2/biosynthesis en_US
dc.subject cyclooxygenase-2 en_US
dc.subject intramucosal melanocytic nevi en_US
dc.subject Melanocytes/enzymology/pathology en_US
dc.subject Melanoma/diagnostic imaging/enzymology/pathology en_US
dc.subject Mouth Mucosa/diagnostic imaging/enzymology/pathology en_US
dc.subject Mouth Neoplasms/diagnostic imaging/enzymology/pathology en_US
dc.subject Nevus/diagnostic imaging/enzymology/pathology en_US
dc.subject oral melanoma en_US
dc.subject Skin Neoplasms/diagnostic imaging/enzymology/pathology en_US
dc.title Immunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/jop.12385
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09


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