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A new 5-alkylresorcinol glucoside derivative from Cybianthus magnus

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dc.contributor.author Cabanillas, B.
dc.contributor.author Vasquez-Ocmin, P.
dc.contributor.author Zebiri, I.
dc.contributor.author Rengifo, E.
dc.contributor.author Sauvain, M.
dc.contributor.author Le, H. L.
dc.contributor.author Vaisberg, A.
dc.contributor.author Voutquenne-Nazabadioko, L.
dc.contributor.author Haddad, M.
dc.date.accessioned 2019-02-06T14:53:07Z
dc.date.available 2019-02-06T14:53:07Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5369
dc.description.abstract One new 5-alkylresorcinol glucoside (1) was isolated from leaves of Cybianthus magnus, along with 12 known compounds, isolated from four plants belonging to Myrsinaceae family (2, 3 isolated from C. magnus; 4–7, 10 and 11 isolated from Myrsine latifolia; 4, 8 and 9 isolated from Myrsine sessiflora; 6, 7, 10, 12 and 13 isolated from Myrsine congesta). Their structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. So far, only nine 5-alkylresorcinol glucosides were isolated from leaves of Grevillea robusta. Since resorcinols are known to exhibit strong cytotoxic activity, compounds 1 and 2 were tested against cell lines 3T3, H460, DU145 and MCF-7 for cytotoxicity in vitro and compounds 3–13 were tested for their antileishmanial activity. Compound 2 displayed a strong cytotoxic activity with IC50 values ranging between 22 and 100 μM for all tested cell lines. Compounds 3–13 were not active against Leishmania amazonensis amastigotes. One new 5-alkylresorcinol glucoside (1) was isolated from leaves of Cybianthus magnus, along with 12 known compounds (2–13), isolated from four plants belonging to Myrsinaceae family. Their structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. Among the tested molecules, only compound 2 displayed a strong cytotoxic activity with IC50 values ranging between 22 and 100 μM for all cell lines tested. en_US
dc.language.iso eng
dc.publisher Taylor & Francis
dc.relation.ispartof urn:issn:1478-6427
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Animals en_US
dc.subject Cell Line, Tumor en_US
dc.subject Cell Survival en_US
dc.subject secondary metabolites en_US
dc.subject Magnetic Resonance Spectroscopy en_US
dc.subject alkylresorcinol en_US
dc.subject anti-leishmaniasis, cytotoxicity en_US
dc.subject Antineoplastic Agents, Phytogenic/isolation & purification/pharmacology en_US
dc.subject Drug Screening Assays, Antitumor en_US
dc.subject Glucosides/chemistry/pharmacology en_US
dc.subject Leishmania/drug effects en_US
dc.subject Myrsinaceae en_US
dc.subject Plant Leaves/chemistry en_US
dc.subject Plant Roots/chemistry en_US
dc.subject Primulaceae/chemistry en_US
dc.subject Resorcinols/chemistry/pharmacology en_US
dc.subject Spectrometry, Mass, Electrospray Ionization en_US
dc.title A new 5-alkylresorcinol glucoside derivative from Cybianthus magnus en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1080/14786419.2015.1056188
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.10
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.01


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