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Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

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dc.contributor.author Merker, Matthias
dc.contributor.author Blin, Camille
dc.contributor.author Mona, Stefano
dc.contributor.author Duforet-Frebourg, Nicolas
dc.contributor.author Lecher, Sophie
dc.contributor.author Willery, Eve
dc.contributor.author Blum, Michael G. B.
dc.contributor.author Rusch-Gerdes, Sabine
dc.contributor.author Mokrousov, Igor
dc.contributor.author Aleksic, Eman
dc.contributor.author Allix-Beguec, Caroline
dc.contributor.author Antierens, Annick
dc.contributor.author Augustynowicz-Kopec, Ewa
dc.contributor.author Ballif, Marie
dc.contributor.author Barletta, Francesca
dc.contributor.author Beck, Hans Peter
dc.contributor.author Barry, Clifton E. 3rd
dc.contributor.author Bonnet, Maryline
dc.contributor.author Borroni, Emanuele
dc.contributor.author Campos-Herrero, Isolina
dc.contributor.author Cirillo, Daniela
dc.contributor.author Cox, Helen
dc.contributor.author Crowe, Suzanne
dc.contributor.author Crudu, Valeriu
dc.contributor.author Diel, Roland
dc.contributor.author Drobniewski, Francis
dc.contributor.author Fauville-Dufaux, Maryse
dc.contributor.author Gagneux, Sebastien
dc.contributor.author Ghebremichael, Solomon
dc.contributor.author Hanekom, Madeleine
dc.contributor.author Hoffner, Sven
dc.contributor.author Jiao, Wei-wei
dc.contributor.author Kalon, Stobdan
dc.contributor.author Kohl, Thomas A.
dc.contributor.author Kontsevaya, Irina
dc.contributor.author Lillebaek, Troels
dc.contributor.author Maeda, Shinji
dc.contributor.author Nikolayevskyy, Vladyslav
dc.contributor.author Rasmussen, Michael
dc.contributor.author Rastogi, Nalin
dc.contributor.author Samper, Sofia
dc.contributor.author Sanchez-Padilla, Elisabeth
dc.contributor.author Savic, Branislava
dc.contributor.author Shamputa, Isdore Chola
dc.contributor.author Shen, Adong
dc.contributor.author Sng, Li-Hwei
dc.contributor.author Stakenas, Petras
dc.contributor.author Toit, Kadri
dc.contributor.author Varaine, Francis
dc.contributor.author Vukovic, Dragana
dc.contributor.author Wahl, Celine
dc.contributor.author Warren, Robin
dc.contributor.author Supply, Philip
dc.contributor.author Niemann, Stefan
dc.contributor.author Wirth, Thierry
dc.date.accessioned 2019-02-06T14:53:07Z
dc.date.available 2019-02-06T14:53:07Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5371
dc.description.abstract Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage. en_US
dc.language.iso eng
dc.publisher Springer Nature
dc.relation.ispartofseries Nature Genetics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Global Health en_US
dc.subject Phylogeny en_US
dc.subject Genotype en_US
dc.subject Mutation en_US
dc.subject Evolution, Molecular en_US
dc.subject Genome, Bacterial en_US
dc.subject Tuberculosis, Multidrug-Resistant/epidemiology/microbiology en_US
dc.subject Biological Evolution en_US
dc.subject Mycobacterium tuberculosis/classification/genetics/isolation & purification en_US
dc.title Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/ng.3195
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07
dc.relation.issn 1546-1718


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