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Neuronal erythropoietin overexpression protects mice against age-related hearing loss (presbycusis)

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dc.contributor.author Monge Naldi, Arianne
dc.contributor.author Belfrage, Celina
dc.contributor.author Jain, Neha
dc.contributor.author Wei, Eric T.
dc.contributor.author Canto Martorell, Belen
dc.contributor.author Gassmann, Max
dc.contributor.author Vogel, Johannes
dc.date.accessioned 2019-02-06T14:53:07Z
dc.date.available 2019-02-06T14:53:07Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5372
dc.description.abstract So far, typical causes of presbycusis such as degeneration of hair cells and/or primary auditory (spiral ganglion) neurons cannot be treated. Because erythropoietin's (Epo) neuroprotective potential has been shown previously, we determined hearing thresholds of juvenile and aged mice overexpressing Epo in neuronal tissues. Behavioral audiometry revealed in contrast to 5 months of age, that 11-month-old Epo-transgenic mice had up to 35 dB lower hearing thresholds between 1.4 and 32 kHz, and at the highest frequencies (50-80 kHz), thresholds could be obtained in aged Epo-transgenic only but not anymore in old C57BL6 control mice. Click-evoked auditory brainstem response showed similar results. Numbers of spiral ganglion neurons in aged C57BL6 but not Epo-transgenic mice were dramatically reduced mainly in the basal turn, the location of high frequencies. In addition, there was a tendency to better preservation of inner and outer hair cells in Epo-transgenic mice. Hence, Epo's known neuroprotective action effectively suppresses the loss of spiral ganglion cells and probably also hair cells and, thus, development of presbycusis in mice. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Neurobiology of Aging
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Neuroprotection en_US
dc.subject Mice, Inbred C57BL en_US
dc.subject Mice, Transgenic en_US
dc.subject ABR en_US
dc.subject Age-related hearing loss (ARHL) en_US
dc.subject Cochlea en_US
dc.subject Erythropoietin/genetics/physiology en_US
dc.subject Evoked Potentials, Auditory/physiology en_US
dc.subject Excitotoxicity en_US
dc.subject Gene Expression Regulation, Developmental/genetics en_US
dc.subject Gene Expression/genetics en_US
dc.subject Hair Cells, Auditory/pathology en_US
dc.subject Nerve Degeneration en_US
dc.subject Neuroprotective Agents en_US
dc.subject Presbycusis/genetics/pathology/prevention & control en_US
dc.subject Spiral ganglion en_US
dc.subject Spiral Ganglion/cytology/pathology en_US
dc.title Neuronal erythropoietin overexpression protects mice against age-related hearing loss (presbycusis) en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.neurobiolaging.2015.08.015
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.26
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.04
dc.relation.issn 1558-1497

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