Universidad Peruana Cayetano Heredia

Inflammation Caused by Praziquantel Treatment Depends on the Location of the Taenia solium Cysticercus in Porcine Neurocysticercosis

Mostrar el registro sencillo del ítem

dc.contributor.author Cangalaya, Carla
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Marzal, Miguel
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author Guerra-Giraldez, Cristina
dc.contributor.author Mahanty, Siddhartha
dc.contributor.author Nash, Theodore E.
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2019-02-06T14:53:09Z
dc.date.available 2019-02-06T14:53:09Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5382
dc.description.abstract BACKGROUND: Neurocysticercosis (NCC), infection of the central nervous system by Taenia solium cysticerci, is a pleomorphic disease. Inflammation around cysticerci is the major cause of disease but is variably present. One factor modulating the inflammatory responses may be the location and characteristics of the brain tissue adjacent to cysticerci. We analyzed and compared the inflammatory responses to cysticerci located in the parenchyma to those in the meninges or cysticerci partially in contact with both the parenchyma and the meninges (corticomeningeal). METHODOLOGY/PRINCIPAL FINDINGS: Histological specimens of brain cysticerci (n = 196) from 11 pigs naturally infected with Taenia solium cysticerci were used. Four pigs were sacrificed after 2 days and four after 5 days of a single dose of praziquantel; 3 pigs did not receive treatment. All pigs were intravenously injected with Evans Blue to assess disruption of the blood-brain barrier. The degree of inflammation was estimated by use of a histological score (ISC) based on the extent of the inflammation in the pericystic areas as assessed in an image composed of several photomicrographs taken at 40X amplification. Parenchymal cysticerci provoked a significantly greater level of pericystic inflammation (higher ISC) after antiparasitic treatment compared to meningeal and corticomeningeal cysticerci. ISC of meningeal cysticerci was not significantly affected by treatment. In corticomeningeal cysticerci, the increase in ISC score was correlated to the extent of the cysticercus adjacent to the brain parenchyma. Disruption of the blood-brain barrier was associated with treatment only in parenchymal tissue. SIGNIFICANCE: Inflammatory response to cysticerci located in the meninges was significantly decreased compared to parenchymal cysticerci. The suboptimal inflammatory response to cysticidal drugs may be the reason subarachnoid NCC is generally refractory to treatment compared to parenchymal NCC. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Treatment Outcome en_US
dc.subject Swine en_US
dc.subject Brain/parasitology/pathology en_US
dc.subject Anthelmintics/adverse effects/therapeutic use en_US
dc.subject Histocytochemistry en_US
dc.subject Inflammation/chemically induced/pathology en_US
dc.subject Meninges/parasitology/pathology en_US
dc.subject Neurocysticercosis/drug therapy/pathology/veterinary en_US
dc.subject Praziquantel/adverse effects/therapeutic use en_US
dc.subject Swine Diseases/drug therapy/pathology en_US
dc.title Inflammation Caused by Praziquantel Treatment Depends on the Location of the Taenia solium Cysticercus in Porcine Neurocysticercosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0004207
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas