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Plasmodium vivax Diversity and Population Structure across Four Continents

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dc.contributor.author Koepfli, Cristian
dc.contributor.author Rodrigues, Priscila T.
dc.contributor.author Antao, Tiago
dc.contributor.author Orjuela-Sanchez, Pamela
dc.contributor.author Van den Eede, Peter
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author van Hong, Nguyen
dc.contributor.author Bendezu, Jorge
dc.contributor.author Erhart, Annette
dc.contributor.author Barnadas, Celine
dc.contributor.author Ratsimbasoa, Arsene
dc.contributor.author Menard, Didier
dc.contributor.author Severini, Carlo
dc.contributor.author Menegon, Michela
dc.contributor.author Nour, Bakri Y. M.
dc.contributor.author Karunaweera, Nadira
dc.contributor.author Mueller, Ivo
dc.contributor.author Ferreira, Marcelo U.
dc.contributor.author Felger, Ingrid
dc.date.accessioned 2019-02-06T14:53:10Z
dc.date.available 2019-02-06T14:53:10Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5386
dc.description.abstract Plasmodium vivax is the geographically most widespread human malaria parasite. To analyze patterns of microsatellite diversity and population structure across countries of different transmission intensity, genotyping data from 11 microsatellite markers was either generated or compiled from 841 isolates from four continents collected in 1999-2008. Diversity was highest in South-East Asia (mean allelic richness 10.0-12.8), intermediate in the South Pacific (8.1-9.9) Madagascar and Sudan (7.9-8.4), and lowest in South America and Central Asia (5.5-7.2). A reduced panel of only 3 markers was sufficient to identify approx. 90% of all haplotypes in South Pacific, African and SE-Asian populations, but only 60-80% in Latin American populations, suggesting that typing of 2-6 markers, depending on the level of endemicity, is sufficient for epidemiological studies. Clustering analysis showed distinct clusters in Peru and Brazil, but little sub-structuring was observed within Africa, SE-Asia or the South Pacific. Isolates from Uzbekistan were exceptional, as a near-clonal parasite population was observed that was clearly separated from all other populations (FST>0.2). Outside Central Asia FST values were highest (0.11-0.16) between South American and all other populations, and lowest (0.04-0.07) between populations from South-East Asia and the South Pacific. These comparisons between P. vivax populations from four continents indicated that not only transmission intensity, but also geographical isolation affect diversity and population structure. However, the high effective population size results in slow changes of these parameters. This persistency must be taken into account when assessing the impact of control programs on the genetic structure of parasite populations. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Cohort Studies en_US
dc.subject Genetics, Population en_US
dc.subject Genetic Variation en_US
dc.subject Genotype en_US
dc.subject Geography en_US
dc.subject Microsatellite Repeats/genetics en_US
dc.subject Asia/epidemiology en_US
dc.subject Africa/epidemiology en_US
dc.subject Cluster Analysis en_US
dc.subject Alleles en_US
dc.subject Haplotypes en_US
dc.subject Americas/epidemiology en_US
dc.subject Linkage Disequilibrium en_US
dc.subject Madagascar/epidemiology en_US
dc.subject Malaria, Vivax/epidemiology/parasitology/transmission en_US
dc.subject Plasmodium vivax/genetics/isolation & purification en_US
dc.title Plasmodium vivax Diversity and Population Structure across Four Continents en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0003872
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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