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Post-treatment vascular leakage and inflammatory responses around brain cysts in porcine neurocysticercosis

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dc.contributor.author Mahanty, Siddhartha
dc.contributor.author Orrego, Miguel Angel
dc.contributor.author Mayta, Holger
dc.contributor.author Marzal, Miguel
dc.contributor.author Cangalaya, Carla
dc.contributor.author Paredes, Adriana
dc.contributor.author Gonzales-Gustavson, Eloy
dc.contributor.author Arroyo, Gianfranco
dc.contributor.author Gonzalez, Armando E.
dc.contributor.author Guerra-Giraldez, Cristina
dc.contributor.author Garcia, Hector H.
dc.contributor.author Nash, Theodore E.
dc.date.accessioned 2019-02-06T14:53:10Z
dc.date.available 2019-02-06T14:53:10Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5388
dc.description.abstract Cysticidal treatment of neurocysticercosis, an infection of humans and pig brains with Taenia solium, results in an early inflammatory response directed to cysts causing seizures and focal neurological manifestations. Treatment-induced pericystic inflammation and its association with blood brain barrier (BBB) dysfunction, as determined by Evans blue (EB) extravasation, was studied in infected untreated and anthelmintic-treated pigs. We compared the magnitude and extent of the pericystic inflammation, presence of EB-stained capsules, the level of damage to the parasite, expression of genes for proinflammatory and regulatory cytokines, chemokines, and tissue remodeling by quantitative PCR assays between treated and untreated infected pigs and between EB-stained (blue) and non stained (clear) cysts. Inflammatory scores were higher in pericystic tissues from en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof urn:issn:1935-2735
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Swine en_US
dc.subject Anthelmintics/therapeutic use en_US
dc.subject Brain Diseases/immunology/veterinary en_US
dc.subject Capillary Permeability en_US
dc.subject Cysts/immunology/veterinary en_US
dc.subject Evans Blue/metabolism en_US
dc.subject Inflammation/etiology en_US
dc.subject Neurocysticercosis/drug therapy/immunology/metabolism/veterinary en_US
dc.subject Swine Diseases/drug therapy/immunology/metabolism en_US
dc.title Post-treatment vascular leakage and inflammatory responses around brain cysts in porcine neurocysticercosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0003577
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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