Universidad Peruana Cayetano Heredia
Metabolic Abnormalities Are Common among South American Hispanics Subjects with Normal Weight or Excess Body Weight: The CRONICAS Cohort Study
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| dc.contributor.author | Benziger, Catherine P. | |
| dc.contributor.author | Bernabé Ortiz, Antonio | |
| dc.contributor.author | Gilman, Robert Hugh | |
| dc.contributor.author | Checkley, William | |
| dc.contributor.author | Smeeth, Liam | |
| dc.contributor.author | Málaga Rodríguez, Germán Javier | |
| dc.contributor.author | Miranda, J. Jaime | |
| dc.date.accessioned | 2019-02-06T14:53:10Z | |
| dc.date.available | 2019-02-06T14:53:10Z | |
| dc.date.issued | 2015 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/5391 | |
| dc.description.abstract | OBJECTIVE: We aimed to characterize metabolic status by body mass index (BMI) status. METHODS: The CRONICAS longitudinal study was performed in an age-and-sex stratified random sample of participants aged 35 years or older in four Peruvian settings: Lima (Peru's capital, costal urban, highly urbanized), urban and rural Puno (both high-altitude), and Tumbes (costal semirural). Data from the baseline study, conducted in 2010, was used. Individuals were classified by BMI as normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), and obese (>/=30 kg/m2), and as metabolically healthy (0-1 metabolic abnormality) or metabolically unhealthy (>/=2 abnormalities). Abnormalities included individual components of the metabolic syndrome, high-sensitivity C-reactive protein, and insulin resistance. RESULTS: A total of 3088 (age 55.6+/-12.6 years, 51.3% females) had all measurements. Of these, 890 (28.8%), 1361 (44.1%) and 837 (27.1%) were normal weight, overweight and obese, respectively. Overall, 19.0% of normal weight in contrast to 54.9% of overweight and 77.7% of obese individuals had >/=3 risk factors (p<0.001). Among normal weight individuals, 43.1% were metabolically unhealthy, and age >/=65 years, female, and highest socioeconomic groups were more likely to have this pattern. In contrast, only 16.4% of overweight and 3.9% of obese individuals were metabolically healthy and, compared to Lima, the rural and urban sites in Puno were more likely to have a metabolically healthier profile. CONCLUSIONS: Most Peruvians with overweight and obesity have additional risk factors for cardiovascular disease, as well as a majority of those with a healthy weight. Prevention programs aimed at individuals with a normal BMI, and those who are overweight and obese, are urgently needed, such as screening for elevated fasting cholesterol and glucose. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Public Library of Science | |
| dc.relation.ispartofseries | PLoS ONE | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Adult | en_US |
| dc.subject | Female | en_US |
| dc.subject | Humans | en_US |
| dc.subject | Male | en_US |
| dc.subject | Cohort Studies | en_US |
| dc.subject | Aged | en_US |
| dc.subject | Middle Aged | en_US |
| dc.subject | Peru/epidemiology | en_US |
| dc.subject | Prevalence | en_US |
| dc.subject | Risk Factors | en_US |
| dc.subject | Multivariate Analysis | en_US |
| dc.subject | Demography | en_US |
| dc.subject | Body Size | en_US |
| dc.subject | Body Mass Index | en_US |
| dc.subject | Metabolic Syndrome/epidemiology | en_US |
| dc.subject | Body Weight | en_US |
| dc.subject | Behavior | en_US |
| dc.subject | Hispanic Americans/statistics & numerical data | en_US |
| dc.subject | Obesity/epidemiology/metabolism | en_US |
| dc.title | Metabolic Abnormalities Are Common among South American Hispanics Subjects with Normal Weight or Excess Body Weight: The CRONICAS Cohort Study | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1371/journal.pone.0138968 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.18 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.04 | |
| dc.relation.issn | 1932-6203 |
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