Universidad Peruana Cayetano Heredia

HPV Prevalence in Multiple Anatomical Sites among Men Who Have Sex with Men in Peru

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dc.contributor.author Blas Blas, Magaly Marlitz
dc.contributor.author Brown, Brandon
dc.contributor.author Menacho Alvirio, Luis Alberto
dc.contributor.author Alva, Isaac E.
dc.contributor.author Silva-Santisteban Portella, Alfonso Alberto
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.date.accessioned 2019-02-06T14:53:10Z
dc.date.available 2019-02-06T14:53:10Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5392
dc.description.abstract BACKGROUND: Human Papilloma Virus (HPV) infection is the most common sexually transmitted viral infection worldwide. HPV is highly prevalent in sexually active men who have sex with men (MSM) and has been associated with anal cancer, penile cancer, and oropharyngeal cancer. METHODS: From March to September 2011, we conducted a cross-sectional study of HPV prevalence among MSM above age 18 years. Participants were recruited using respondent driven sampling at Clinica Cayetano Heredia. All participants provided anal, genital, and oral samples for HPV DNA testing, and blood for HIV and HPV antibody testing. RESULTS: A total of 200 MSM were recruited in the study. The mean age was 34 years (range 18-59 years, SD = 9.4) and101 participants were HIV negative (99 HIV positive). HPV 6/11/16/18 or quadrivalent HPV vaccine (HPV4) genotype seroprevalence among HIV negative and positive MSM was 64.3% (55%-75.9%) and 93.8% (87.6%-99.2%) respectively (p<0.001). HIV positivity was associated with a higher prevalence of HPV4 and HPV 16/18 DNA at external genital sites and the anal canal. HPV4 DNA prevalence at external genital sites among HIV negative and positive MSM was 14.9% and 28.7% (p = 0.02) respectively, at anal canal was 50.9% and 79.0% (p = 0.001), and at the oral cavity was 9.9% and 8.5% (p = 0.6). CONCLUSIONS: HPV4 seroprevalence was high in our study among both HIV positives and negatives, with HPV DNA prevalence much lower, and the anal canal being the anatomical site with the highest HPV DNA prevalence. HPV prevention interventions are needed among MSM at high-risk for HIV infection. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Urban Population en_US
dc.subject Comorbidity en_US
dc.subject Homosexuality, Male en_US
dc.subject Sexual Behavior en_US
dc.subject Condoms/statistics & numerical data en_US
dc.subject HIV Infections/epidemiology en_US
dc.subject Bisexuality en_US
dc.subject Anal Canal/virology en_US
dc.subject Condylomata Acuminata/epidemiology/virology en_US
dc.subject DNA, Viral/analysis en_US
dc.subject Genitalia, Male/virology en_US
dc.subject Mouth/virology en_US
dc.subject Organ Specificity en_US
dc.subject Papillomaviridae/classification/genetics/isolation & purification en_US
dc.subject Papillomavirus Infections/epidemiology/transmission en_US
dc.title HPV Prevalence in Multiple Anatomical Sites among Men Who Have Sex with Men in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0139524
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.12
dc.relation.issn 1932-6203


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