Universidad Peruana Cayetano Heredia

Hotspots of Malaria Transmission in the Peruvian Amazon: Rapid Assessment through a Parasitological and Serological Survey

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dc.contributor.author Rosas-Aguirre, Angel
dc.contributor.author Speybroeck, Niko
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Rosanas-Urgell, Anna
dc.contributor.author Carrasco Escobar, Gabriel
dc.contributor.author Rodriguez, Hugo
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Contreras-Mancilla, Juan
dc.contributor.author Alava, Freddy
dc.contributor.author Soares, Irene S.
dc.contributor.author Remarque, Edmond
dc.contributor.author D Alessandro, Umberto
dc.contributor.author Erhart, Annette
dc.date.accessioned 2019-02-06T14:53:10Z
dc.date.available 2019-02-06T14:53:10Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5393
dc.description.abstract BACKGROUND: With low and markedly seasonal malaria transmission, increasingly sensitive tools for better stratifying the risk of infection and targeting control interventions are needed. A cross-sectional survey to characterize the current malaria transmission patterns, identify hotspots, and detect recent changes using parasitological and serological measures was conducted in three sites of the Peruvian Amazon. MATERIAL AND METHODS: After full census of the study population, 651 participants were interviewed, clinically examined and had a blood sample taken for the detection of malaria parasites (microscopy and PCR) and antibodies against P. vivax (PvMSP119, PvAMA1) and P. falciparum (PfGLURP, PfAMA1) antigens by ELISA. Risk factors for malaria infection (positive PCR) and malaria exposure (seropositivity) were assessed by multivariate survey logistic regression models. Age-specific seroprevalence was analyzed using a reversible catalytic conversion model based on maximum likelihood for generating seroconversion rates (SCR, lambda). SaTScan was used to detect spatial clusters of serology-positive individuals within each site. RESULTS: The overall parasite prevalence by PCR was low, i.e. 3.9% for P. vivax and 6.7% for P. falciparum, while the seroprevalence was substantially higher, 33.6% for P. vivax and 22.0% for P. falciparum, with major differences between study sites. Age and location (site) were significantly associated with P. vivax exposure; while location, age and outdoor occupation were associated with P. falciparum exposure. P. falciparum seroprevalence curves showed a stable transmission throughout time, while for P. vivax transmission was better described by a model with two SCRs. The spatial analysis identified well-defined clusters of P. falciparum seropositive individuals in two sites, while it detected only a very small cluster of P. vivax exposure. CONCLUSION: The use of a single parasitological and serological malaria survey has proven to be an efficient and accurate method to characterize the species specific heterogeneity in malaria transmission at micro-geographical level as well as to identify recent changes in transmission. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Humans en_US
dc.subject Young Adult en_US
dc.subject Child en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Risk Factors en_US
dc.subject Multivariate Analysis en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium vivax en_US
dc.subject Geography en_US
dc.subject Species Specificity en_US
dc.subject Incidence en_US
dc.subject Seroepidemiologic Studies en_US
dc.subject Factor Analysis, Statistical en_US
dc.subject Malaria, Falciparum/blood/epidemiology/parasitology/transmission en_US
dc.subject Malaria, Vivax/blood/epidemiology/parasitology/transmission en_US
dc.title Hotspots of Malaria Transmission in the Peruvian Amazon: Rapid Assessment through a Parasitological and Serological Survey en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0137458
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn 1932-6203


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