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Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011

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dc.contributor.author Ballard, Sarah-Blythe
dc.contributor.author Reaves, Erik J.
dc.contributor.author Luna, C. Giannina
dc.contributor.author Silva, Maria E.
dc.contributor.author Rocha, Claudio
dc.contributor.author Heitzinger, Kristen
dc.contributor.author Saito, Mayuko
dc.contributor.author Apaza, Sonia
dc.contributor.author Espetia, Susan
dc.contributor.author Blazes, David L.
dc.contributor.author Tilley, Drake H.
dc.contributor.author Guzman Aguilar, Rene C.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Bausch, Daniel G.
dc.date.accessioned 2019-02-06T14:53:10Z
dc.date.available 2019-02-06T14:53:10Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5395
dc.description.abstract BACKGROUND: Successful vaccination strategies against norovirus will require understanding the burden of disease and relevant genotypes in populations. However, few data are available from cohort studies of adults living in low- and middle-income countries (LMIC). MATERIALS AND METHODS: We conducted a nested case-control study within a Peruvian military cohort to characterize the burden of norovirus infection, predominant genotypes, and associated symptoms from 2004 through 2011. Randomly selected case and control stools were tested for norovirus, bacteria, and parasites. The odds ratio of the association between norovirus infection and diarrhea was estimated using multiple logistic regression and co-infection adjusted attributable fractions were calculated. RESULTS: Of the 3,818 cohort study participants, 624 developed diarrhea. Overall and norovirus-associated diarrhea incidence rates were 42.3 and 6.0 per 100 person-years, respectively. The most prevalent norovirus genogroup was GII (72.5%, 29/40), which was associated with diarrhea (AOR 3.4, 95% CI: 1.3-8.7, P = 0.012). The co-infection adjusted GII attributable fraction was 6.4%. DISCUSSION: Norovirus was a frequent cause of diarrhea in an adult population followed longitudinally in an LMIC setting. Vaccine strategies should consider targeting adults in endemic settings and special populations that could serve as community transmission sources. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Cohort Studies en_US
dc.subject Peru/epidemiology en_US
dc.subject Animals en_US
dc.subject Logistic Models en_US
dc.subject Prevalence en_US
dc.subject Case-Control Studies en_US
dc.subject Genotype en_US
dc.subject Comorbidity en_US
dc.subject Incidence en_US
dc.subject Endemic Diseases en_US
dc.subject Bacterial Infections/epidemiology/microbiology en_US
dc.subject Caliciviridae Infections/epidemiology/virology en_US
dc.subject Coinfection/epidemiology en_US
dc.subject Diarrhea/epidemiology en_US
dc.subject Feces/microbiology/parasitology/virology en_US
dc.subject Military Personnel/statistics & numerical data en_US
dc.subject Nematode Infections/epidemiology/parasitology en_US
dc.subject Norovirus/genetics/physiology en_US
dc.subject Protozoan Infections/epidemiology/parasitology en_US
dc.title Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011 en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0131646
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.02
dc.relation.issn 1932-6203

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