dc.contributor.author |
Grandjean, Louis |
|
dc.contributor.author |
Iwamoto, Tomotada |
|
dc.contributor.author |
Lithgow, Anna |
|
dc.contributor.author |
Gilman, Robert Hugh |
|
dc.contributor.author |
Arikawa, Kentaro |
|
dc.contributor.author |
Nakanishi, Noriko |
|
dc.contributor.author |
Martin, Laura |
|
dc.contributor.author |
Castillo, Edith |
|
dc.contributor.author |
Alarcon, Valentina |
|
dc.contributor.author |
Coronel, Jorge |
|
dc.contributor.author |
Solano, Walter |
|
dc.contributor.author |
Aminian, Minoo |
|
dc.contributor.author |
Guezala, Claudia |
|
dc.contributor.author |
Rastogi, Nalin |
|
dc.contributor.author |
Couvin, David |
|
dc.contributor.author |
Sheen Cortavarria, Patricia |
|
dc.contributor.author |
Zimic-Peralta, Mirko Juan |
|
dc.contributor.author |
Moore, David Alexander James |
|
dc.date.accessioned |
2019-02-06T14:53:10Z |
|
dc.date.available |
2019-02-06T14:53:10Z |
|
dc.date.issued |
2015 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/5398 |
|
dc.description.abstract |
BACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis. METHODS: To investigate the association of Mycobacterium tuberculosis bacterial genotype with drug-resistance. Drug susceptibility testing together with genotyping using both 15-loci MIRU-typing and spoligotyping, was performed on 2,139 culture positive isolates, each from a different patient in Lima, Peru. Demographic, geospatial and socio-economic data were collected using questionnaires, global positioning equipment and the latest national census. RESULTS: The Latin American Mediterranean (LAM) clade (OR 2.4, p<0.001) was significantly associated with drug-resistance and alone accounted for more than half of all drug resistance in the region. Previously treated patients, prisoners and genetically clustered cases were also significantly associated with drug-resistance (OR's 2.5, 2.4 and 1.8, p<0.001, p<0.05, p<0.001 respectively). CONCLUSIONS: Tuberculosis disease caused by the LAM clade was more likely to be drug resistant independent of important clinical, genetic and socio-economic confounding factors. Explanations for this include; the preferential co-evolution of LAM strains in a Latin American population, a LAM strain bacterial genetic background that favors drug-resistance or the "founder effect" from pre-existing LAM strains disproportionately exposed to drugs. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Public Library of Science |
|
dc.relation.ispartofseries |
PLoS ONE |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Peru |
en_US |
dc.subject |
Adult |
en_US |
dc.subject |
Female |
en_US |
dc.subject |
Humans |
en_US |
dc.subject |
Male |
en_US |
dc.subject |
Middle Aged |
en_US |
dc.subject |
Genotype |
en_US |
dc.subject |
Drug Resistance, Bacterial/genetics |
en_US |
dc.subject |
Mycobacterium tuberculosis/drug effects/genetics/isolation & purification |
en_US |
dc.subject |
Tuberculosis, Multidrug-Resistant/epidemiology/microbiology |
en_US |
dc.title |
The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1371/journal.pone.0126271 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.07 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.01.05 |
|
dc.relation.issn |
1932-6203 |
|