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The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru

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dc.contributor.author Grandjean, Louis
dc.contributor.author Iwamoto, Tomotada
dc.contributor.author Lithgow, Anna
dc.contributor.author Gilman, Robert H.
dc.contributor.author Arikawa, Kentaro
dc.contributor.author Nakanishi, Noriko
dc.contributor.author Martin, Laura
dc.contributor.author Castillo, Edith
dc.contributor.author Alarcon, Valentina
dc.contributor.author Coronel, Jorge
dc.contributor.author Solano, Walter
dc.contributor.author Aminian, Minoo
dc.contributor.author Guezala, Claudia
dc.contributor.author Rastogi, Nalin
dc.contributor.author Couvin, David
dc.contributor.author Sheen, Patricia
dc.contributor.author Zimic, Mirko
dc.contributor.author Moore, David A. J.
dc.date.accessioned 2019-02-06T14:53:10Z
dc.date.available 2019-02-06T14:53:10Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5398
dc.description.abstract BACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis. METHODS: To investigate the association of Mycobacterium tuberculosis bacterial genotype with drug-resistance. Drug susceptibility testing together with genotyping using both 15-loci MIRU-typing and spoligotyping, was performed on 2,139 culture positive isolates, each from a different patient in Lima, Peru. Demographic, geospatial and socio-economic data were collected using questionnaires, global positioning equipment and the latest national census. RESULTS: The Latin American Mediterranean (LAM) clade (OR 2.4, p<0.001) was significantly associated with drug-resistance and alone accounted for more than half of all drug resistance in the region. Previously treated patients, prisoners and genetically clustered cases were also significantly associated with drug-resistance (OR's 2.5, 2.4 and 1.8, p<0.001, p<0.05, p<0.001 respectively). CONCLUSIONS: Tuberculosis disease caused by the LAM clade was more likely to be drug resistant independent of important clinical, genetic and socio-economic confounding factors. Explanations for this include; the preferential co-evolution of LAM strains in a Latin American population, a LAM strain bacterial genetic background that favors drug-resistance or the "founder effect" from pre-existing LAM strains disproportionately exposed to drugs. en_US
dc.language.iso eng
dc.publisher PLoS
dc.relation.ispartof urn:issn:1932-6203
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Genotype en_US
dc.subject Drug Resistance, Bacterial/genetics en_US
dc.subject Mycobacterium tuberculosis/drug effects/genetics/isolation & purification en_US
dc.subject Tuberculosis, Multidrug-Resistant/epidemiology/microbiology en_US
dc.title The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0126271
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05


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