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The potential of canine sentinels for reemerging Trypanosoma cruzi transmission

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dc.contributor.author Castillo Neyra, Ricardo
dc.contributor.author Chou Chu, Lily
dc.contributor.author Quispe-Machaca, Victor
dc.contributor.author Ancca-Juarez, Jenny
dc.contributor.author Malaga Chavez, Fernando S.
dc.contributor.author Bastos Mazuelos, Milagros
dc.contributor.author Naquira Velarde, Cesar Gabriel
dc.contributor.author Bern, Caryn
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Levy, Michael Z.
dc.date.accessioned 2019-02-06T14:53:12Z
dc.date.available 2019-02-06T14:53:12Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5406
dc.description.abstract BACKGROUND: Chagas disease, a vector-borne disease transmitted by triatomine bugs and caused by the parasite Trypanosoma cruzi, affects millions of people in the Americas. In Arequipa, Peru, indoor residual insecticide spraying campaigns are routinely conducted to eliminate Triatoma infestans, the only vector in this area. Following insecticide spraying, there is risk of vector return and reinitiation of parasite transmission. Dogs are important reservoirs of T. cruzi and may play a role in reinitiating transmission in previously sprayed areas. Dogs may also serve as indicators of reemerging transmission. METHODS: We conducted a cross-sectional serological screening to detect T. cruzi antibodies in dogs, in conjunction with an entomological vector collection survey at the household level, in a disease endemic area that had been treated with insecticide 13 years prior. Spatial clustering of infected animals and vectors was assessed using Ripley's K statistic, and the odds of being seropositive for dogs proximate to infected colonies was estimated with multivariate logistic regression. RESULTS: There were 106 triatomine-infested houses (41.1%), and 45 houses infested with T. cruzi-infected triatomine insects (17.4%). Canine seroprevalence in the area was 12.3% (n=154); all seropositive dogs were 9 months old or older. We observed clustering of vectors carrying the parasite, but no clustering of seropositive dogs. The age- and sex-adjusted odds ratio between seropositivity to T. cruzi and proximity to an infected triatomine (</=50m) was 5.67 (95% CI: 1.12-28.74; p=0.036). CONCLUSIONS: Targeted control of reemerging transmission can be achieved by improved understanding of T. cruzi in canine populations. Our results suggest that dogs may be useful sentinels to detect re-initiation of transmission following insecticide treatment. Integration of canine T. cruzi blood sampling into existing interventions for zoonotic disease control (e.g., rabies vaccination programs) can be an effective method of increasing surveillance and improving understanding of disease distribution. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Preventive Veterinary Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Male en_US
dc.subject Trypanosoma cruzi en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Peru/epidemiology en_US
dc.subject Animals en_US
dc.subject ELISA en_US
dc.subject Prevalence en_US
dc.subject Spatial Analysis en_US
dc.subject Spatial analysis en_US
dc.subject Triatoma infestans en_US
dc.subject Dogs en_US
dc.subject Antibodies, Protozoan/blood en_US
dc.subject Triatoma/parasitology en_US
dc.subject Seroepidemiologic Studies en_US
dc.subject Chagas Disease/epidemiology/parasitology/transmission/veterinary en_US
dc.subject Dog en_US
dc.subject Dog Diseases/epidemiology/parasitology/transmission en_US
dc.subject Endemic Diseases/veterinary en_US
dc.subject Insect Vectors/parasitology en_US
dc.subject Sentinel surveillance en_US
dc.subject Sentinel Surveillance/veterinary en_US
dc.subject Trypanosoma cruzi/isolation & purification en_US
dc.title The potential of canine sentinels for reemerging Trypanosoma cruzi transmission en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.prevetmed.2015.04.014
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#4.03.00
dc.relation.issn 1873-1716


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