The potential of canine sentinels for reemerging Trypanosoma cruzi transmission

Castillo Neyra, Ricardo; Gilman, Robert Hugh; Levy, Michael Z.; Chou Chu, Lily; Bern, Caryn; Malaga Chavez, Fernando S.; Quispe-Machaca, Victor; Bastos Mazuelos, Milagros; Naquira Velarde, Cesar Gabriel; Ancca-Juarez, Jenny

dc.contributor.author	Castillo Neyra, Ricardo
dc.contributor.author	Chou Chu, Lily
dc.contributor.author	Quispe-Machaca, Victor
dc.contributor.author	Ancca-Juarez, Jenny
dc.contributor.author	Malaga Chavez, Fernando S.
dc.contributor.author	Bastos Mazuelos, Milagros
dc.contributor.author	Naquira Velarde, Cesar Gabriel
dc.contributor.author	Bern, Caryn
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Levy, Michael Z.
dc.date.accessioned	2019-02-06T14:53:12Z
dc.date.available	2019-02-06T14:53:12Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5406
dc.description.abstract	BACKGROUND: Chagas disease, a vector-borne disease transmitted by triatomine bugs and caused by the parasite Trypanosoma cruzi, affects millions of people in the Americas. In Arequipa, Peru, indoor residual insecticide spraying campaigns are routinely conducted to eliminate Triatoma infestans, the only vector in this area. Following insecticide spraying, there is risk of vector return and reinitiation of parasite transmission. Dogs are important reservoirs of T. cruzi and may play a role in reinitiating transmission in previously sprayed areas. Dogs may also serve as indicators of reemerging transmission. METHODS: We conducted a cross-sectional serological screening to detect T. cruzi antibodies in dogs, in conjunction with an entomological vector collection survey at the household level, in a disease endemic area that had been treated with insecticide 13 years prior. Spatial clustering of infected animals and vectors was assessed using Ripley's K statistic, and the odds of being seropositive for dogs proximate to infected colonies was estimated with multivariate logistic regression. RESULTS: There were 106 triatomine-infested houses (41.1%), and 45 houses infested with T. cruzi-infected triatomine insects (17.4%). Canine seroprevalence in the area was 12.3% (n=154); all seropositive dogs were 9 months old or older. We observed clustering of vectors carrying the parasite, but no clustering of seropositive dogs. The age- and sex-adjusted odds ratio between seropositivity to T. cruzi and proximity to an infected triatomine (</=50m) was 5.67 (95% CI: 1.12-28.74; p=0.036). CONCLUSIONS: Targeted control of reemerging transmission can be achieved by improved understanding of T. cruzi in canine populations. Our results suggest that dogs may be useful sentinels to detect re-initiation of transmission following insecticide treatment. Integration of canine T. cruzi blood sampling into existing interventions for zoonotic disease control (e.g., rabies vaccination programs) can be an effective method of increasing surveillance and improving understanding of disease distribution.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Preventive Veterinary Medicine
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Female	en_US
dc.subject	Male	en_US
dc.subject	Trypanosoma cruzi	en_US
dc.subject	Cross-Sectional Studies	en_US
dc.subject	Peru/epidemiology	en_US
dc.subject	Animals	en_US
dc.subject	ELISA	en_US
dc.subject	Prevalence	en_US
dc.subject	Spatial Analysis	en_US
dc.subject	Spatial analysis	en_US
dc.subject	Triatoma infestans	en_US
dc.subject	Dogs	en_US
dc.subject	Antibodies, Protozoan/blood	en_US
dc.subject	Triatoma/parasitology	en_US
dc.subject	Seroepidemiologic Studies	en_US
dc.subject	Chagas Disease/epidemiology/parasitology/transmission/veterinary	en_US
dc.subject	Dog	en_US
dc.subject	Dog Diseases/epidemiology/parasitology/transmission	en_US
dc.subject	Endemic Diseases/veterinary	en_US
dc.subject	Insect Vectors/parasitology	en_US
dc.subject	Sentinel surveillance	en_US
dc.subject	Sentinel Surveillance/veterinary	en_US
dc.subject	Trypanosoma cruzi/isolation & purification	en_US
dc.title	The potential of canine sentinels for reemerging Trypanosoma cruzi transmission	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.prevetmed.2015.04.014
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#4.03.00
dc.relation.issn	1873-1716