Universidad Peruana Cayetano Heredia

Bottlenecks in domestic animal populations can facilitate the emergence of Trypanosoma cruzi, the aetiological agent of Chagas disease

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dc.contributor.author Levy, Michael Z.
dc.contributor.author Tustin, Aaron
dc.contributor.author Castillo Neyra, Ricardo
dc.contributor.author Mabud, Tarub S.
dc.contributor.author Levy, Katelyn
dc.contributor.author Barbu, Corentin M.
dc.contributor.author Quispe-Machaca, Victor R.
dc.contributor.author Ancca-Juarez, Jenny
dc.contributor.author Borrini-Mayori, Katty
dc.contributor.author Naquira Velarde, Cesar Gabriel
dc.contributor.author Ostfeld, Richard S.
dc.date.accessioned 2019-02-06T14:53:12Z
dc.date.available 2019-02-06T14:53:12Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5407
dc.description.abstract Faeces-mediated transmission of Trypanosoma cruzi (the aetiological agent of Chagas disease) by triatomine insects is extremely inefficient. Still, the parasite emerges frequently, and has infected millions of people and domestic animals. We synthesize here the results of field and laboratory studies of T. cruzi transmission conducted in and around Arequipa, Peru. We document the repeated occurrence of large colonies of triatomine bugs (more than 1000) with very high infection prevalence (more than 85%). By inoculating guinea pigs, an important reservoir of T. cruzi in Peru, and feeding triatomine bugs on them weekly, we demonstrate that, while most animals quickly control parasitaemia, a subset of animals remains highly infectious to vectors for many months. However, we argue that the presence of these persistently infectious hosts is insufficient to explain the observed prevalence of T. cruzi in vector colonies. We posit that seasonal rains, leading to a fluctuation in the price of guinea pig food (alfalfa), leading to annual guinea pig roasts, leading to a concentration of vectors on a small subpopulation of animals maintained for reproduction, can propel T. cruzi through vector colonies and create a considerable force of infection for a pathogen whose transmission might otherwise fizzle out. en_US
dc.language.iso eng
dc.publisher Royal Society Publishing
dc.relation.ispartofseries Proceedings - Royal Society. Biological Sciences
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Trypanosoma cruzi en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Peru/epidemiology en_US
dc.subject Animals en_US
dc.subject Population Dynamics en_US
dc.subject Prevalence en_US
dc.subject Chagas disease en_US
dc.subject Triatoma infestans en_US
dc.subject Trypanosoma cruzi/physiology en_US
dc.subject Guinea Pigs en_US
dc.subject bottleneck en_US
dc.subject Chagas Disease/epidemiology/parasitology/transmission/veterinary en_US
dc.subject Disease Reservoirs/parasitology/veterinary en_US
dc.subject guinea pigs en_US
dc.subject Insect Vectors/parasitology/physiology en_US
dc.subject Parasitemia/epidemiology/parasitology/transmission/veterinary en_US
dc.subject Rodent Diseases/epidemiology/parasitology/transmission en_US
dc.subject Triatoma/parasitology/physiology en_US
dc.title Bottlenecks in domestic animal populations can facilitate the emergence of Trypanosoma cruzi, the aetiological agent of Chagas disease en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1098/rspb.2014.2807
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.00
dc.relation.issn 1471-2954


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