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Field evaluation of a dual rapid diagnostic test for HIV infection and syphilis in Lima, Peru

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dc.contributor.author Bristow, Claire C.
dc.contributor.author Leon, Segundo R.
dc.contributor.author Huang, Emily
dc.contributor.author Brown, Brandon J.
dc.contributor.author Ramos, Lourdes B.
dc.contributor.author Vargas, Silver K.
dc.contributor.author Flores, Juan A.
dc.contributor.author Caceres, Carlos F.
dc.contributor.author Klausner, Jeffrey D.
dc.date.accessioned 2019-02-06T14:53:40Z
dc.date.available 2019-02-06T14:53:40Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5448
dc.description.abstract OBJECTIVES: Screening for HIV and syphilis in key populations is recommended by the WHO to reduce the morbidity, mortality and transmission associated with undiagnosed and untreated infections. Rapid point-of-care tests that can detect multiple infections with a single fingerprick whole blood specimen using a single device are gaining popularity. We evaluated the field performance of a rapid dual HIV and syphilis test in people at high risk of HIV and syphilis infections. METHODS: Participants included men who have sex with men and transgender women recruited in Lima, Peru. Reference standard testing for detection of HIV and syphilis infections, conducted using blood samples from venipuncture, included Treponema pallidum particle agglutination and fourth-generation HIV enzyme immunoassay for which positive results had a confirmation HIV Western blot test. For the evaluation test, SD BIOLINE HIV/Syphilis Duo test (Standard Diagnostics, Korea), a fingerprick blood specimen was used. Sensitivity and specificity were calculated and the exact binomial method was used to determine 95% CIs. RESULTS: A total of 415 participants were recruited for the study. The dual test sensitivity for detection of T. pallidum infection was 89.2% (95% CI 83.5% to 93.5%) and specificity 98.8% (95% CI 96.5% to 99.8%). For detection of HIV infection, the sensitivity of the dual test was 99.1% (95% CI 94.8% to 100%) and specificity 99.4% (95% CI 97.7% to 99.9%). CONCLUSIONS: This high performing dual test should be considered for the use in clinical settings to increase uptake of simultaneous testing of HIV and syphilis and accelerate time to treatment for those who need it. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartof urn:issn:1472-3263
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Sensitivity and Specificity en_US
dc.subject Peru/epidemiology en_US
dc.subject Homosexuality, Male en_US
dc.subject Coinfection en_US
dc.subject Antibodies, Bacterial/blood en_US
dc.subject Transgender Persons en_US
dc.subject Treponema pallidum/immunology en_US
dc.subject Quality Control en_US
dc.subject Chromatography, Affinity/standards en_US
dc.subject Community Health Centers en_US
dc.subject DIAGNOSIS en_US
dc.subject HIV Antibodies/blood en_US
dc.subject HIV Infections/complications/diagnosis/epidemiology en_US
dc.subject HIV TESTING en_US
dc.subject Mass Screening/methods en_US
dc.subject SYPHILIS en_US
dc.subject Syphilis Serodiagnosis en_US
dc.subject Syphilis/complications/diagnosis/epidemiology en_US
dc.title Field evaluation of a dual rapid diagnostic test for HIV infection and syphilis in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/sextrans-2015-052326
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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