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Is restless legs syndrome associated with chronic mountain sickness?

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dc.contributor.author Vizcarra-Escobar, Darwin
dc.contributor.author Mendiola-Yamasato, Andrea
dc.contributor.author Risco-Rocca, Jorge
dc.contributor.author Marinos-Velarde, Alejandro
dc.contributor.author Juarez-Belaunde, Alan
dc.contributor.author Anculle-Arauco, Victor
dc.contributor.author Rivera-Chira, Maria
dc.date.accessioned 2019-02-06T14:53:41Z
dc.date.available 2019-02-06T14:53:41Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5451
dc.description.abstract BACKGROUND: Restless legs syndrome (RLS) and chronic mountain sickness (CMS) share physiological traits. Our objective was to explore a possible association between RLS and CMS. METHODS: We carried a cross-sectional study with male subjects living between 4100 and 4300 m above sea level. Participants underwent a clinical interview, physical examination, electrocardiographic (EKG) recording, and spirometry. We classified subjects into CMS, Limbo, and healthy high-altitude dwellers (hHAD), according to their Quinghai score and hematocrit levels. We applied the "Paradigm of questions for epidemiological studies of RLS," The International Restless Leg Syndrome Study Group Scale, and the Pittsburgh Sleep Quality Index. Logistic regression analysis was used to determine the association between variables. RESULTS: Seventy-eight male subjects were included. Forty subjects were hHAD, 23 were CMS patients, and 15 participants were considered as Limbo. CMS and Limbo subjects had a higher frequency of RLS (p <0.05). Limbo subjects had the highest severity score for RLS. There were no differences in age, body mass index (BMI), or tobacco use between RLS patients and non-sufferers. In the multivariate analysis, CMS was not associated with RLS diagnosis. Oxygen saturation (p = 0.019), poor sleep quality (p <0.01), and Quinghai score of >/=6 (p = 0.026) were independently associated with RLS diagnosis. CONCLUSIONS: Our results did not show a direct association between RLS and CMS; however, RLS was associated with reduced oxygen saturation. Hence, RLS could represent an early clinical manifestation of hypoxia, or, in CMS natural history, an early sign of maladaptation to high altitude. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1878-5506
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Chronic Disease en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Surveys and Questionnaires en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Logistic Models en_US
dc.subject Severity of Illness Index en_US
dc.subject Hypoxia en_US
dc.subject Chronic mountain sickness en_US
dc.subject Spirometry en_US
dc.subject Electrocardiography en_US
dc.subject Altitude Sickness/blood/complications/epidemiology en_US
dc.subject Hematocrit en_US
dc.subject Oxygen/blood en_US
dc.subject Restless legs syndrome en_US
dc.subject Restless Legs Syndrome/blood/etiology en_US
dc.title Is restless legs syndrome associated with chronic mountain sickness? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.sleep.2015.03.013

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