Is restless legs syndrome associated with chronic mountain sickness?

Vizcarra-Escobar, Darwin; Anculle-Arauco, Victor; Rivera Chira, Maria Concepcion; Mendiola-Yamasato, Andrea; Marinos-Velarde, Alejandro; Juarez-Belaunde, Alan; Risco-Rocca, Jorge

dc.contributor.author	Vizcarra-Escobar, Darwin
dc.contributor.author	Mendiola-Yamasato, Andrea
dc.contributor.author	Risco-Rocca, Jorge
dc.contributor.author	Marinos-Velarde, Alejandro
dc.contributor.author	Juarez-Belaunde, Alan
dc.contributor.author	Anculle-Arauco, Victor
dc.contributor.author	Rivera Chira, Maria Concepcion
dc.date.accessioned	2019-02-06T14:53:41Z
dc.date.available	2019-02-06T14:53:41Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5451
dc.description.abstract	BACKGROUND: Restless legs syndrome (RLS) and chronic mountain sickness (CMS) share physiological traits. Our objective was to explore a possible association between RLS and CMS. METHODS: We carried a cross-sectional study with male subjects living between 4100 and 4300 m above sea level. Participants underwent a clinical interview, physical examination, electrocardiographic (EKG) recording, and spirometry. We classified subjects into CMS, Limbo, and healthy high-altitude dwellers (hHAD), according to their Quinghai score and hematocrit levels. We applied the "Paradigm of questions for epidemiological studies of RLS," The International Restless Leg Syndrome Study Group Scale, and the Pittsburgh Sleep Quality Index. Logistic regression analysis was used to determine the association between variables. RESULTS: Seventy-eight male subjects were included. Forty subjects were hHAD, 23 were CMS patients, and 15 participants were considered as Limbo. CMS and Limbo subjects had a higher frequency of RLS (p <0.05). Limbo subjects had the highest severity score for RLS. There were no differences in age, body mass index (BMI), or tobacco use between RLS patients and non-sufferers. In the multivariate analysis, CMS was not associated with RLS diagnosis. Oxygen saturation (p = 0.019), poor sleep quality (p <0.01), and Quinghai score of >/=6 (p = 0.026) were independently associated with RLS diagnosis. CONCLUSIONS: Our results did not show a direct association between RLS and CMS; however, RLS was associated with reduced oxygen saturation. Hence, RLS could represent an early clinical manifestation of hypoxia, or, in CMS natural history, an early sign of maladaptation to high altitude.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Sleep Medicine
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Peru	en_US
dc.subject	Adolescent	en_US
dc.subject	Adult	en_US
dc.subject	Humans	en_US
dc.subject	Male	en_US
dc.subject	Young Adult	en_US
dc.subject	Chronic Disease	en_US
dc.subject	Cross-Sectional Studies	en_US
dc.subject	Surveys and Questionnaires	en_US
dc.subject	Aged	en_US
dc.subject	Middle Aged	en_US
dc.subject	Peru/epidemiology	en_US
dc.subject	Logistic Models	en_US
dc.subject	Severity of Illness Index	en_US
dc.subject	Hypoxia	en_US
dc.subject	Chronic mountain sickness	en_US
dc.subject	Spirometry	en_US
dc.subject	Electrocardiography	en_US
dc.subject	Altitude Sickness/blood/complications/epidemiology	en_US
dc.subject	Hematocrit	en_US
dc.subject	Oxygen/blood	en_US
dc.subject	Restless legs syndrome	en_US
dc.subject	Restless Legs Syndrome/blood/etiology	en_US
dc.title	Is restless legs syndrome associated with chronic mountain sickness?	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.sleep.2015.03.013
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.25
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn	1878-5506