Novel rat model for neurocysticercosis using Taenia solium

Chile Andrade, Nancy; Clark, Taryn; Gavidia, Cesar M.; García Lescano, Héctor Hugo; Ortega, Ynes; Gilman, Robert Hugh; Medina, Roxana; Rodriguez, Silvia; Carmen, Rogger; Mamani, Javier; Verastegui Pimentel, Manuela Renee; Ccopa, Fredy; Mejia, Alan; Angulo, Noelia

dc.contributor.author	Verastegui Pimentel, Manuela Renee
dc.contributor.author	Mejia, Alan
dc.contributor.author	Clark, Taryn
dc.contributor.author	Gavidia, Cesar M.
dc.contributor.author	Mamani, Javier
dc.contributor.author	Ccopa, Fredy
dc.contributor.author	Angulo, Noelia
dc.contributor.author	Chile Andrade, Nancy
dc.contributor.author	Carmen, Rogger
dc.contributor.author	Medina, Roxana
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Rodriguez, Silvia
dc.contributor.author	Ortega, Ynes
dc.contributor.author	Gilman, Robert Hugh
dc.date.accessioned	2019-02-06T14:53:41Z
dc.date.available	2019-02-06T14:53:41Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5456
dc.description.abstract	Neurocysticercosis is caused by Taenia solium infecting the central nervous system and is the leading cause of acquired epilepsy and convulsive conditions worldwide. Research into the pathophysiology of the disease and appropriate treatment is hindered by lack of cost-effective and physiologically similar animal models. We generated a novel rat neurocysticercosis model using intracranial infection with activated T. solium oncospheres. Holtzman rats were infected in two separate groups: the first group was inoculated extraparenchymally and the second intraparenchymally, with different doses of activated oncospheres. The groups were evaluated at three different ages. Histologic examination of the tissue surrounding T. solium cysticerci was performed. Results indicate that generally infected rats developed cysticerci in the brain tissue after 4 months, and the cysticerci were observed in the parenchymal, ventricle, or submeningeal brain tissue. The route of infection did not have a statistically significant effect on the proportion of rats that developed cysticerci, and there was no dependence on infection dose. However, rat age was crucial to the success of the infection. Epilepsy was observed in 9% of rats with neurocysticercosis. In histologic examination, a layer of collagen tissue, inflammatory infiltrate cells, perivascular infiltrate, angiogenesis, spongy change, and mass effect were observed in the tissue surrounding the cysts. This study presents a suitable animal model for the study of human neurocysticercosis.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	American Journal of Pathology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Animals	en_US
dc.subject	Rats	en_US
dc.subject	Taenia solium	en_US
dc.subject	Disease Models, Animal	en_US
dc.subject	Neurocysticercosis/parasitology/pathology	en_US
dc.subject	Brain/parasitology/pathology	en_US
dc.subject	Rats, Sprague-Dawley	en_US
dc.title	Novel rat model for neurocysticercosis using Taenia solium	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.ajpath.2015.04.015
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn	1525-2191