Universidad Peruana Cayetano Heredia

Does discontinuous involvement of a prostatic needle biopsy core by adenocarcinoma correlate with a large tumor focus at radical prostatectomy?

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dc.contributor.author Arias-Stella, Javier A. 3rd
dc.contributor.author Varma, Kavita R.
dc.contributor.author Montoya-Cerrillo, Diego
dc.contributor.author Gupta, Nilesh S.
dc.contributor.author Williamson, Sean R.
dc.date.accessioned 2019-02-06T14:53:42Z
dc.date.available 2019-02-06T14:53:42Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5458
dc.description.abstract When prostate needle biopsies are involved discontinuously by tumor, no consensus remains on the optimal method of tumor quantification. We investigated whether discontinuous biopsy involvement usually results from a large tumor focus or multiple small foci. Prostate needle biopsies with discontinuous tumor and corresponding whole-mounted radical prostatectomies from 2008 to 2013 were analyzed. Linear length and percentage of biopsy involvement were measured both including and subtracting the benign intervening tissue. The corresponding region of the prostatectomy specimen was evaluated for tumor size and multifocality. From over 800 biopsy sets and 400 prostatectomies performed annually, 40 patients met inclusion criteria. Excluding benign tissue, length and percentage of biopsy involvement ranged from 1 to 7 mm and 5% to 66% (median 2.5 mm, 20%), whereas including intervening tissue yielded 4 to 15.5 mm and 25% to 100%, (median 7 mm, 70%), respectively. Benign intervening tissue measured from 2 to 10.5 mm (median 3.5 mm). In 31 patients (78%), a single tumor focus was present in the corresponding region of the prostate (the dominant tumor in 25/31). In 9 patients, multiple small foci were present. Eleven patients could have been excluded from active surveillance eligibility by measuring tumor from end to end (>50% involvement), of whom only 1 met criteria for clinically insignificant cancer at prostatectomy. Discontinuous tumor in a prostate biopsy often results from a single tumor focus in the corresponding region of the prostate (78%). Therefore, we recommend that an end-to-end measurement be provided, with accompanying diagnostic comment that this often correlates with the size of a single tumor focus. en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries American Journal of Surgical Pathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Neoplasm Staging en_US
dc.subject Biopsy, Large-Core Needle en_US
dc.subject Pathology, Surgical en_US
dc.subject Adenocarcinoma/pathology en_US
dc.subject Neoplasm Grading en_US
dc.subject Prostatectomy en_US
dc.subject Prostatic Neoplasms/pathology en_US
dc.title Does discontinuous involvement of a prostatic needle biopsy core by adenocarcinoma correlate with a large tumor focus at radical prostatectomy? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1097/PAS.0000000000000344
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.11
dc.relation.issn 1532-0979


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