Burden of Norovirus and Rotavirus in Children After Rotavirus Vaccine Introduction, Cochabamba, Bolivia

Webman, Rachel; Gilman, Robert Hugh; McAtee, Casey L.; Torrico, Faustino; Bern, Caryn; Apaza, Sonia; Saito, Mayuko; Ribera, Jose P.; Soria, Richard; Challappa, Roxanna; Lozano, Daniel; Mejia, Carolina; Pajuelo Travezaño, Monica Jhenny; Espetia, Susan

dc.contributor.author	McAtee, Casey L.
dc.contributor.author	Webman, Rachel
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Mejia, Carolina
dc.contributor.author	Bern, Caryn
dc.contributor.author	Apaza, Sonia
dc.contributor.author	Espetia, Susan
dc.contributor.author	Pajuelo Travezaño, Monica Jhenny
dc.contributor.author	Saito, Mayuko
dc.contributor.author	Challappa, Roxanna
dc.contributor.author	Soria, Richard
dc.contributor.author	Ribera, Jose P.
dc.contributor.author	Lozano, Daniel
dc.contributor.author	Torrico, Faustino
dc.date.accessioned	2019-02-06T14:57:36Z
dc.date.available	2019-02-06T14:57:36Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5461
dc.description.abstract	The effectiveness of rotavirus vaccine in the field may set the stage for a changing landscape of diarrheal illness affecting children worldwide. Norovirus and rotavirus are the two major viral enteropathogens of childhood. This study describes the prevalence of norovirus and rotavirus 2 years after widespread rotavirus vaccination in Cochabamba, Bolivia. Stool samples from hospitalized children with acute gastroenteritis (AGE) and outpatients aged 5-24 months without AGE were recruited from an urban hospital serving Bolivia's third largest city. Both viruses were genotyped, and norovirus GII.4 was further sequenced. Norovirus was found much more frequently than rotavirus. Norovirus was detected in 69/201 (34.3%) of specimens from children with AGE and 13/71 (18.3%) of those without diarrhea. Rotavirus was detected in 38/201 (18.9%) of diarrheal specimens and 3/71 (4.2%) of non-diarrheal specimens. Norovirus GII was identified in 97.8% of norovirus-positive samples; GII.4 was the most common genotype (71.4% of typed specimens). Rotavirus G3P[8] was the most prevalent rotavirus genotype (44.0% of typed specimens) and G2P[4] was second most prevalent (16.0% of typed specimens). This community is likely part of a trend toward norovirus predominance over rotavirus in children after widespread vaccination against rotavirus.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Female	en_US
dc.subject	Humans	en_US
dc.subject	Male	en_US
dc.subject	Child, Preschool	en_US
dc.subject	Infant	en_US
dc.subject	Odds Ratio	en_US
dc.subject	Prevalence	en_US
dc.subject	Genotype	en_US
dc.subject	Hospitals	en_US
dc.subject	Urban Population	en_US
dc.subject	Polymerase Chain Reaction	en_US
dc.subject	Bolivia/epidemiology	en_US
dc.subject	Antibodies, Viral/blood	en_US
dc.subject	Caliciviridae Infections/epidemiology/virology	en_US
dc.subject	Gastroenteritis/epidemiology/prevention & control/virology	en_US
dc.subject	Norovirus/genetics	en_US
dc.subject	Rotavirus Infections/epidemiology/prevention & control	en_US
dc.subject	Rotavirus Vaccines/immunology	en_US
dc.subject	Rotavirus/genetics	en_US
dc.title	Burden of Norovirus and Rotavirus in Children After Rotavirus Vaccine Introduction, Cochabamba, Bolivia	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.15-0203
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645