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Burden of Norovirus and Rotavirus in Children After Rotavirus Vaccine Introduction, Cochabamba, Bolivia

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dc.contributor.author McAtee, Casey L.
dc.contributor.author Webman, Rachel
dc.contributor.author Gilman, Robert H.
dc.contributor.author Mejia, Carolina
dc.contributor.author Bern, Caryn
dc.contributor.author Apaza, Sonia
dc.contributor.author Espetia, Susan
dc.contributor.author Pajuelo, Monica
dc.contributor.author Saito, Mayuko
dc.contributor.author Challappa, Roxanna
dc.contributor.author Soria, Richard
dc.contributor.author Ribera, Jose P.
dc.contributor.author Lozano, Daniel
dc.contributor.author Torrico, Faustino
dc.date.accessioned 2019-02-06T14:57:36Z
dc.date.available 2019-02-06T14:57:36Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5461
dc.description.abstract The effectiveness of rotavirus vaccine in the field may set the stage for a changing landscape of diarrheal illness affecting children worldwide. Norovirus and rotavirus are the two major viral enteropathogens of childhood. This study describes the prevalence of norovirus and rotavirus 2 years after widespread rotavirus vaccination in Cochabamba, Bolivia. Stool samples from hospitalized children with acute gastroenteritis (AGE) and outpatients aged 5-24 months without AGE were recruited from an urban hospital serving Bolivia's third largest city. Both viruses were genotyped, and norovirus GII.4 was further sequenced. Norovirus was found much more frequently than rotavirus. Norovirus was detected in 69/201 (34.3%) of specimens from children with AGE and 13/71 (18.3%) of those without diarrhea. Rotavirus was detected in 38/201 (18.9%) of diarrheal specimens and 3/71 (4.2%) of non-diarrheal specimens. Norovirus GII was identified in 97.8% of norovirus-positive samples; GII.4 was the most common genotype (71.4% of typed specimens). Rotavirus G3P[8] was the most prevalent rotavirus genotype (44.0% of typed specimens) and G2P[4] was second most prevalent (16.0% of typed specimens). This community is likely part of a trend toward norovirus predominance over rotavirus in children after widespread vaccination against rotavirus. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:1476-1645
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Child, Preschool en_US
dc.subject Infant en_US
dc.subject Odds Ratio en_US
dc.subject Prevalence en_US
dc.subject Genotype en_US
dc.subject Hospitals en_US
dc.subject Urban Population en_US
dc.subject Polymerase Chain Reaction en_US
dc.subject Bolivia/epidemiology en_US
dc.subject Antibodies, Viral/blood en_US
dc.subject Caliciviridae Infections/epidemiology/virology en_US
dc.subject Gastroenteritis/epidemiology/prevention & control/virology en_US
dc.subject Norovirus/genetics en_US
dc.subject Rotavirus Infections/epidemiology/prevention & control en_US
dc.subject Rotavirus Vaccines/immunology en_US
dc.subject Rotavirus/genetics en_US
dc.title Burden of Norovirus and Rotavirus in Children After Rotavirus Vaccine Introduction, Cochabamba, Bolivia en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.15-0203
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06


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