Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model

Praet, Nicolas; García Lescano, Héctor Hugo; Gilman, Robert Hugh; Bustos Palomino, Javier Arturo; Rodriguez, Silvia; Zimic-Peralta, Mirko Juan; Gabriel, Sarah; Castillo Berrios, Yesenia; Dorny, Pierre; Gonzalez Zariquiey, Armando Emiliano

dc.contributor.author	Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author	Bustos Palomino, Javier Arturo
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Rodriguez, Silvia
dc.contributor.author	Zimic-Peralta, Mirko Juan
dc.contributor.author	Castillo Berrios, Yesenia
dc.contributor.author	Praet, Nicolas
dc.contributor.author	Gabriel, Sarah
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Dorny, Pierre
dc.date.accessioned	2019-02-06T14:57:38Z
dc.date.available	2019-02-06T14:57:38Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5466
dc.description.abstract	Taenia solium cysticercosis is a common parasitic infection of humans and pigs. We evaluated the posttreatment evolution of circulating parasite-specific antigen titers in 693 consecutive blood samples from 50 naturally infected cysticercotic pigs, which received different regimes of antiparasitic drugs (N = 39, 7 groups), prednisone (N = 5), or controls (N = 6). Samples were collected from baseline to week 10 after treatment, when pigs were euthanized and carefully dissected at necropsy. Antigen levels decreased proportionally to the efficacy of treatment and correlated with the remaining viable cysts at necropsy (Pearson's p = 0.67, P = 0.000). A decrease of 5 times in antigen levels (logarithmic scale) compared with baseline was found in 20/26 pigs free of cysts at necropsy, compared with 1/24 of those who had persisting viable cysts (odds ratio [OR] = 76.7, 95% confidence interval [CI] = 8.1-3308.6, P < 0.001). Antigen monitoring reflects the course of infection in the pig. If a similar correlation exists in infected humans, this assay may provide a minimally invasive and easy monitoring assay to assess disease evolution and efficacy of antiparasitic treatment in human neurocysticercosis.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Female	en_US
dc.subject	Male	en_US
dc.subject	Enzyme-Linked Immunosorbent Assay	en_US
dc.subject	Animals	en_US
dc.subject	Treatment Outcome	en_US
dc.subject	Disease Models, Animal	en_US
dc.subject	Drug Therapy, Combination	en_US
dc.subject	Albendazole/administration & dosage/therapeutic use	en_US
dc.subject	Anticestodal Agents/administration & dosage/therapeutic use	en_US
dc.subject	Antigens, Helminth/blood/immunology	en_US
dc.subject	Benzimidazoles/administration & dosage/therapeutic use	en_US
dc.subject	Cysticercosis/drug therapy/immunology	en_US
dc.subject	Neurocysticercosis/drug therapy/immunology	en_US
dc.subject	Praziquantel/administration & dosage/therapeutic use	en_US
dc.subject	Swine Diseases/drug therapy/immunology/parasitology	en_US
dc.subject	Swine/parasitology	en_US
dc.subject	Taenia solium/immunology	en_US
dc.title	Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.15-0370
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645