Universidad Peruana Cayetano Heredia

Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model

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dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Rodriguez, Silvia
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Castillo Berrios, Yesenia
dc.contributor.author Praet, Nicolas
dc.contributor.author Gabriel, Sarah
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Dorny, Pierre
dc.date.accessioned 2019-02-06T14:57:38Z
dc.date.available 2019-02-06T14:57:38Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5466
dc.description.abstract Taenia solium cysticercosis is a common parasitic infection of humans and pigs. We evaluated the posttreatment evolution of circulating parasite-specific antigen titers in 693 consecutive blood samples from 50 naturally infected cysticercotic pigs, which received different regimes of antiparasitic drugs (N = 39, 7 groups), prednisone (N = 5), or controls (N = 6). Samples were collected from baseline to week 10 after treatment, when pigs were euthanized and carefully dissected at necropsy. Antigen levels decreased proportionally to the efficacy of treatment and correlated with the remaining viable cysts at necropsy (Pearson's p = 0.67, P = 0.000). A decrease of 5 times in antigen levels (logarithmic scale) compared with baseline was found in 20/26 pigs free of cysts at necropsy, compared with 1/24 of those who had persisting viable cysts (odds ratio [OR] = 76.7, 95% confidence interval [CI] = 8.1-3308.6, P < 0.001). Antigen monitoring reflects the course of infection in the pig. If a similar correlation exists in infected humans, this assay may provide a minimally invasive and easy monitoring assay to assess disease evolution and efficacy of antiparasitic treatment in human neurocysticercosis. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Male en_US
dc.subject Enzyme-Linked Immunosorbent Assay en_US
dc.subject Animals en_US
dc.subject Treatment Outcome en_US
dc.subject Disease Models, Animal en_US
dc.subject Drug Therapy, Combination en_US
dc.subject Albendazole/administration & dosage/therapeutic use en_US
dc.subject Anticestodal Agents/administration & dosage/therapeutic use en_US
dc.subject Antigens, Helminth/blood/immunology en_US
dc.subject Benzimidazoles/administration & dosage/therapeutic use en_US
dc.subject Cysticercosis/drug therapy/immunology en_US
dc.subject Neurocysticercosis/drug therapy/immunology en_US
dc.subject Praziquantel/administration & dosage/therapeutic use en_US
dc.subject Swine Diseases/drug therapy/immunology/parasitology en_US
dc.subject Swine/parasitology en_US
dc.subject Taenia solium/immunology en_US
dc.title Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.15-0370
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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