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Calcified neurocysticercosis associates with hippocampal atrophy: a population-based study

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dc.contributor.author Del Brutto, Oscar H.
dc.contributor.author Salgado, Perla
dc.contributor.author Lama, Julio
dc.contributor.author Del Brutto, Victor J.
dc.contributor.author Campos, Xavier
dc.contributor.author Zambrano, Mauricio
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2019-02-06T14:57:39Z
dc.date.available 2019-02-06T14:57:39Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5482
dc.description.abstract Calcified neurocysticercosis has been associated with hippocampal atrophy in patients with refractory epilepsy, but the relevance of this association in the population at large is unknown. We assessed calcified cysticerci and its association with hippocampal atrophy in elderly persons living in Atahualpa, an Ecuadorian village endemic for neurocysticercosis. All Atahualpa residents >/= 60 years of age were invited to undergo computed tomography/magnetic resonance imaging for neurocysticercosis detection. Twenty-eight (11%) out of 248 enrolled persons had calcified cysticerci (case-patients) and were matched 1:1 by age, sex, and years of education to individuals without neurocysticercosis on computed tomography/magnetic resonance imaging (controls). Four case-patients and none of the controls had epilepsy (P = 0.134). Cognitive performance was similar across both groups. The Scheltens' medial temporal atrophy scale was used for hippocampal rating in case-patients and matched controls without neurocysticercosis. Mean score in the Scheltens' scale was higher in case-patients than in controls (P < 0.001). Atrophic hippocampi were noticed in 19 case-patients and five controls (P = 0.003). Atrophy was bilateral in 11 case-patients and unilateral in eight. All case-patients with unilateral hippocampal atrophy had at least one ipsilateral calcification. This study shows an association between calcified cysticerci and hippocampal atrophy and raises the possibility of an inflammation-mediated hippocampal damage as the responsible mechanism for these findings. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Aged en_US
dc.subject Tomography, X-Ray Computed en_US
dc.subject Magnetic Resonance Imaging en_US
dc.subject Calcinosis en_US
dc.subject Atrophy en_US
dc.subject Ecuador/epidemiology en_US
dc.subject Hippocampus/pathology en_US
dc.subject Neurocysticercosis/diagnostic imaging/epidemiology/pathology en_US
dc.title Calcified neurocysticercosis associates with hippocampal atrophy: a population-based study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.14-0453
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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