Universidad Peruana Cayetano Heredia

Soil-Transmitted Helminth Infections Are Associated With an Increase in Human Papillomavirus Prevalence and a T-Helper Type 2 Cytokine Signature in Cervical Fluids

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dc.contributor.author Gravitt, Patti E.
dc.contributor.author Marks, Morgan
dc.contributor.author Kosek, Margaret
dc.contributor.author Huang, Christine
dc.contributor.author Cabrera, Lilia
dc.contributor.author Olortegui, Maribel Paredes
dc.contributor.author Medrano, Alberto Mejia
dc.contributor.author Trigoso, Dixner R.
dc.contributor.author Qureshi, Sarah
dc.contributor.author Bardales, Gustavo S.
dc.contributor.author Manrique-Hinojosa, Javier
dc.contributor.author Cardenas, Albert Z.
dc.contributor.author Larraondo, Manuel A.
dc.contributor.author Cok, Jaime
dc.contributor.author Qeadan, Fares
dc.contributor.author Siracusa, Mark
dc.contributor.author Gilman, Robert Hugh
dc.date.accessioned 2019-02-06T14:57:40Z
dc.date.available 2019-02-06T14:57:40Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5488
dc.description.abstract BACKGROUND: An ecological correlation between invasive cervical cancer incidence and burden of soil-transmitted helminths (STH) is hypothesized to explain the excess in detectable human papillomavirus (HPV) infection in Latin America, via a global T-helper type 2 (Th2)-biased mucosal immune response secondary to STH infection. METHODS: The association between current STH infection and HPV prevalence was compared in regions of Peru where STH is or is not endemic. Adjusted prevalence ratios (PRs) with robust variance were estimated as an effect measure of STH infection on HPV prevalence in each study site. Soluble immune marker profiles in STH-infected and STH-uninfected women were compared using Spearman rank correlation with the Sidak correction. RESULTS: Among women in the helminth-endemic region of the Peruvian Amazon, those with STH infection women had a 60% higher prevalence of HPV, compared with those without STH infection (PR, 1.6; 95% confidence interval, 1.0-2.7). Non-STH parasitic/protozoal infections in the non-STH-endemic population of Peru were not associated with HPV prevalence. In Iquitos, A Th2 immune profile was observed in cervical fluid from helminth-infected women but not helminth-uninfected women. CONCLUSIONS: A proportion of the increased HPV prevalence at older ages observed in Latin America may be due to a population-level difference in the efficiency of immunological control of HPV across the lifespan due to endemic STH infection. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject age en_US
dc.subject Pilot Projects en_US
dc.subject prevalence en_US
dc.subject parasite en_US
dc.subject cervical cancer en_US
dc.subject Cervix Uteri/metabolism en_US
dc.subject Cytokines/metabolism en_US
dc.subject Gene Expression Regulation/immunology en_US
dc.subject Helminthiasis/complications/epidemiology/transmission en_US
dc.subject human papillomavirus en_US
dc.subject Papillomaviridae/isolation & purification en_US
dc.subject Papillomavirus Infections/complications/epidemiology/immunology/metabolism en_US
dc.subject soil-transmitted helminth en_US
dc.subject Soil/parasitology en_US
dc.subject T-Lymphocytes, Helper-Inducer/metabolism en_US
dc.title Soil-Transmitted Helminth Infections Are Associated With an Increase in Human Papillomavirus Prevalence and a T-Helper Type 2 Cytokine Signature in Cervical Fluids en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/jiv498
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6613


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