Universidad Peruana Cayetano Heredia

Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia

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dc.contributor.author Adaui, Vanessa
dc.contributor.author Lye, Lon-Fye
dc.contributor.author Akopyants, Natalia S.
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Garcia, Lineth
dc.contributor.author Maes, Ilse
dc.contributor.author De Doncker, Simonne
dc.contributor.author Dobson, Deborah E.
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Dujardin, Jean-Claude
dc.contributor.author Beverley, Stephen M.
dc.date.accessioned 2019-02-06T14:57:40Z
dc.date.available 2019-02-06T14:57:40Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5489
dc.description.abstract Cutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with resistance in vitro, and the factors responsible for treatment failure in patients are not well understood. Many isolates of L. braziliensis (>25%) contain a double-stranded RNA virus named Leishmaniavirus 1 (LRV1), which has also been reported in Leishmania guyanensis, for which an association with increased pathology, metastasis, and parasite replication was found in murine models. Here we probed the relationship of LRV1 to drug treatment success and disease in 97 L. braziliensis-infected patients from Peru and Bolivia. In vitro cultures were established, parasites were typed as L. braziliensis, and the presence of LRV1 was determined by reverse transcription-polymerase chain reaction, followed by sequence analysis. LRV1 was associated significantly with an increased risk of treatment failure (odds ratio, 3.99; P = .04). There was no significant association with intrinsic Sb(V) resistance among parasites, suggesting that treatment failure arises from LRV1-mediated effects on host metabolism and/or parasite survival. The association of LRV1 with clinical drug treatment failure could serve to guide more-effective treatment of tegumentary disease caused by L. braziliensis. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Cohort Studies en_US
dc.subject Peru/epidemiology en_US
dc.subject drug resistance en_US
dc.subject Treatment Failure en_US
dc.subject leishmaniasis en_US
dc.subject Bolivia/epidemiology en_US
dc.subject Leishmaniavirus/classification/genetics en_US
dc.subject antimony drug treatment en_US
dc.subject Antimony/therapeutic use en_US
dc.subject Antiprotozoal Agents/therapeutic use en_US
dc.subject Drug Resistance en_US
dc.subject drug treatment failure en_US
dc.subject L. braziliensis en_US
dc.subject Leishmania braziliensis/virology en_US
dc.subject Leishmaniasis, Mucocutaneous/drug therapy/epidemiology/parasitology/virology en_US
dc.subject RNA viruses en_US
dc.subject Totivirus en_US
dc.subject Viannia en_US
dc.title Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/jiv354
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6613


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