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Genome-level determination of Plasmodium falciparum blood-stage targets of malarial clinical immunity in the Peruvian Amazon

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dc.contributor.author Torres Fajardo, Katherine Jessica
dc.contributor.author Castrillon, Carlos E.
dc.contributor.author Moss, Eli L.
dc.contributor.author Saito, Mayuko
dc.contributor.author Tenorio, Roy
dc.contributor.author Molina, Douglas M.
dc.contributor.author Davies, Huw
dc.contributor.author Neafsey, Daniel E.
dc.contributor.author Felgner, Philip
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.date.accessioned 2019-02-06T14:57:40Z
dc.date.available 2019-02-06T14:57:40Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5490
dc.description.abstract BACKGROUND: Persons with blood-stage Plasmodium falciparum parasitemia in the absence of symptoms are considered to be clinically immune. We hypothesized that asymptomatic subjects with P. falciparum parasitemia would differentially recognize a subset of P. falciparum proteins on a genomic scale. METHODS AND FINDINGS: Compared with symptomatic subjects, sera from clinically immune, asymptomatically infected individuals differentially recognized 51 P. falciparum proteins, including the established vaccine candidate PfMSP1. Novel, hitherto unstudied hypothetical proteins and other proteins not previously recognized as potential vaccine candidates were also differentially recognized. Genes encoding the proteins differentially recognized by the Peruvian clinically immune individuals exhibited a significant enrichment of nonsynonymous nucleotide variation, an observation consistent with these genes undergoing immune selection. CONCLUSIONS: A limited set of P. falciparum protein antigens was associated with the development of naturally acquired clinical immunity in the low-transmission setting of the Peruvian Amazon. These results imply that, even in a low-transmission setting, an asexual blood-stage vaccine designed to reduce clinical malaria symptoms will likely need to contain large numbers of often-polymorphic proteins, a finding at odds with many current efforts in the design of vaccines against asexual blood-stage P. falciparum. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Child en_US
dc.subject Middle Aged en_US
dc.subject immunology en_US
dc.subject malaria en_US
dc.subject Antibodies, Protozoan/immunology en_US
dc.subject Antigens, Protozoan/genetics/immunology en_US
dc.subject geographic medicine en_US
dc.subject Malaria Vaccines/immunology en_US
dc.subject Malaria, Falciparum/blood/immunology en_US
dc.subject Parasitemia/blood/immunology/parasitology en_US
dc.subject Plasmodium falciparum/genetics/immunology en_US
dc.subject Protozoan Proteins/blood/genetics/immunology en_US
dc.subject systems biology en_US
dc.title Genome-level determination of Plasmodium falciparum blood-stage targets of malarial clinical immunity in the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/jiu614
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6613


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