DSpace Repository

Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g

Show simple item record

dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Zegarra, Jaime
dc.contributor.author Cam, Luis
dc.contributor.author Llanos, Raul
dc.contributor.author Pezo, Alonso
dc.contributor.author Cruz, Karen
dc.contributor.author Zea-Vera, Alonso
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Campos, Miguel
dc.contributor.author Bellomo, Sicilia
dc.date.accessioned 2019-02-06T14:57:41Z
dc.date.available 2019-02-06T14:57:41Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5494
dc.description.abstract BACKGROUND: Lactoferrin (LF) is a broad-spectrum antimicrobial and immunomodulatory milk glycoprotein. OBJECTIVE: To determine the effect of bovine LF on the prevention of the first episode of late-onset sepsis in Peruvian infants. METHODS: We conducted a pilot randomized placebo-controlled double blind study in infants with a birth weight (BW) less than 2500g in 3 Neonatal Units in Lima. Patients were randomized to receive bovine LF 200mg/kg/d or placebo for 4 weeks. RESULTS: One hundred and ninety neonates with a BW of 1591 +/- 408 g and a gestational age of 32.1 +/- 2.6 weeks were enrolled. Overall, 33 clinically defined first late-onset sepsis events occurred. The cumulative sepsis incidence in the LF group was 12/95 (12.6%) versus 21/95 (22.1%) in the placebo group, and 20% (8/40) versus 37.5% (15/40) for infants less than or equal to 1500 g. The hazard ratio of LF, after adjustment by BW, was 0.507 (95% CI: 0.249-1.034). There were 4 episodes of culture-proven sepsis in the LF group versus 4 in the placebo group. Considering that children did not received the intervention until the start of oral or tube feeding, we ran a secondary exploratory analysis using time since the start of the treatment; in this model, LF achieved significance. There were no serious adverse events attributable to the intervention. CONCLUSIONS: Overall sepsis occurred less frequently in the LF group than in the control group. Although the primary outcome did not reach statistical significance, the confidence interval is suggestive of an effect that justifies a larger trial. en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries Pediatric Infectious Disease Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Humans en_US
dc.subject Treatment Outcome en_US
dc.subject Pilot Projects en_US
dc.subject Double-Blind Method en_US
dc.subject Anti-Infective Agents/administration & dosage en_US
dc.subject Infant, Newborn en_US
dc.subject Immunologic Factors/administration & dosage en_US
dc.subject Lactoferrin/administration & dosage en_US
dc.subject Placebos/administration & dosage en_US
dc.subject Sepsis/prevention & control en_US
dc.title Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1097/INF.0000000000000593
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1532-0987


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics