Universidad Peruana Cayetano Heredia

Diarrheagenic Escherichia coli phylogroups are associated with antibiotic resistance and duration of diarrheal episode

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dc.contributor.author Mosquito, Susan
dc.contributor.author Pons, Maria J.
dc.contributor.author Riveros Ramirez, Maribel Denise
dc.contributor.author Ruiz, Joaquim
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.date.accessioned 2019-02-06T14:57:41Z
dc.date.available 2019-02-06T14:57:41Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5495
dc.description.abstract Conventionally, in Escherichia coli, phylogenetic groups A and B1 are associated with commensal strains while B2 and D are associated with extraintestinal strains. The aim of this study was to evaluate diarrheagenic (DEC) and commensal E. coli phylogeny and its association with antibiotic resistance and clinical characteristics of the diarrheal episode. Phylogenetic groups and antibiotic resistance of 369 E. coli strains (commensal strains and DEC from children with or without diarrhea) isolated from Peruvian children <1 year of age were determined by a Clermont triplex PCR and Kirby-Bauer method, respectively. The distribution of the 369 E. coli strains among the 4 phylogenetic groups was A (40%), D (31%), B1 (21%), and B2 (8%). DEC-control strains were more associated with group A while DEC-diarrhea strains were more associated with group D (P < 0.05). There was a tendency (P = 0.06) for higher proportion of persistent diarrhea (>/= 14 days) among severe groups (B2 and D) in comparison with nonsevere groups (A and B1). Strains belonging to group D presented significantly higher percentages of multidrug resistance than the rest of the groups (P > 0.01). In summary, DEC-diarrhea strains were more associated with group D than strains from healthy controls. en_US
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartofseries Scientific World Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Infant en_US
dc.subject Time Factors en_US
dc.subject Phylogeny en_US
dc.subject Case-Control Studies en_US
dc.subject Diarrhea, Infantile/drug therapy/microbiology en_US
dc.subject Drug Resistance, Microbial/genetics en_US
dc.subject Escherichia coli Infections/drug therapy/microbiology en_US
dc.subject Escherichia coli/classification/drug effects/genetics en_US
dc.subject Virulence/genetics en_US
dc.title Diarrheagenic Escherichia coli phylogroups are associated with antibiotic resistance and duration of diarrheal episode en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1155/2015/610403
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.05.08
dc.relation.issn 1537-744X


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