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Urbanisation but not biomass fuel smoke exposure is associated with asthma prevalence in four resource-limited settings

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dc.contributor.author Gaviola, Chelsea
dc.contributor.author Miele, Catherine H.
dc.contributor.author Wise, Robert A.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Jaganath, Devan
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Hansel, Nadia N.
dc.contributor.author Checkley, William
dc.date.accessioned 2019-02-06T14:57:42Z
dc.date.available 2019-02-06T14:57:42Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5496
dc.description.abstract BACKGROUND: Urbanisation is an important contributor to the prevalence of asthma worldwide, and the burden of this effect in low-income and middle-income countries undergoing rapid industrialisation appears to be growing. We sought to characterise adult asthma prevalence across four geographically diverse settings in Peru and identify both individual and environmental risk factors associated with adult asthma. METHODS: We collected sociodemographics, clinical history and spirometry in adults aged >/=35 years. We defined asthma as meeting one of the three criteria: physician diagnosis, self-report of wheezing attack or use of asthma medications. We used multivariable logistic regression to assess individual and environmental factors associated with adult asthma. RESULTS: We analysed data from 2953 participants (mean age 55 years; 49% male). Overall asthma prevalence was 7.1%, which varied with urbanisation: highest in Lima (14.5%), followed by urban Puno (4.0%), semiurban Tumbes (3.8%) and rural Puno (1.8%). In multivariable analysis, being male (OR=0.60, 95% CI 0.39 to 0.93) and living at high altitude (OR=0.26, 95% CI 0.16 to 0.42) were associated with lower odds of having asthma, whereas living in an urban setting (OR=4.72, 95% CI 3.15 to 7.23) and family history of asthma (OR=1.83, 95% CI 1.19 to 2.73) were associated with higher odds. Current daily exposure to biomass fuel smoke (OR=1.18, 95% CI 0.70 to 1.91) and smoking (OR=0.99, 95% CI 0.73 to 1.22) were not associated with asthma. CONCLUSIONS: These findings confirm that urbanisation is an environmental risk factor of asthma, questions biomass fuel smoke exposure as an important risk factor and proposes high altitude as possibly protective against the development of asthma. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Thorax
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Risk Factors en_US
dc.subject Asthma en_US
dc.subject Rural Population en_US
dc.subject Air Pollution, Indoor/adverse effects en_US
dc.subject Prognosis en_US
dc.subject Biomass en_US
dc.subject Urbanization en_US
dc.subject Asthma Epidemiology en_US
dc.subject Asthma/epidemiology/etiology en_US
dc.subject Smoke/adverse effects en_US
dc.subject Spirometry en_US
dc.title Urbanisation but not biomass fuel smoke exposure is associated with asthma prevalence in four resource-limited settings en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/thoraxjnl-2015-207584
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1468-3296


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