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Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review

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dc.contributor.author Gonzales, G. F.
dc.contributor.author Chaupis, D.
dc.date.accessioned 2019-02-06T14:59:05Z
dc.date.available 2019-02-06T14:59:05Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/5511
dc.description.abstract Populations living at high altitudes (HA), particularly in the Peruvian Central Andes, are characterised by presenting subjects with erythrocytosis and others with excessive erythrocytosis (EE)(Hb>21 g dl(-1) ). EE is associated with chronic mountain sickness (CMS), or lack of adaptation to HA. Testosterone is an erythropoietic hormone and it may play a role on EE at HA. The objective of the present review was to summarise findings on role of serum T levels on adaptation at HA and genes acting on this process. Men at HA without EE have higher androstenedione levels and low ratio androstenedione/testosterone than men with EE, suggesting low activity of 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and this could be a mechanism of adaptation to HA. Higher conversion of dehydroepiandrosterone to testosterone in men with EE suggests nigher 17beta-HSD activity. Men with CMS at Peruvian Central Andes have two genes SENP1, and ANP32D with higher transcriptional response to hypoxia relative to those without. SUMO‐specific protease 1 (SENP1) is an erythropoiesis regulator, which is essential for the stability and activity of hypoxia‐inducible factor 1 (HIF‐1α) under hypoxia. SENP1 reverses the hormone‐augmented SUMOylation of androgen receptor (AR) increasing the transcription activity of AR.In conclusion, increased androgen activity is related with CMS. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof urn:issn:1439-0272
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Male en_US
dc.subject chronic mountain sickness en_US
dc.subject Chronic Disease en_US
dc.subject South America en_US
dc.subject Polycythemia/blood en_US
dc.subject Adaptation, Physiological/genetics en_US
dc.subject Altitude Sickness/blood/genetics/physiopathology en_US
dc.subject Androgen receptor en_US
dc.subject Androgens/blood/genetics en_US
dc.subject como en_US
dc.subject haemoglobin en_US
dc.subject Receptors, Androgen/metabolism en_US
dc.subject SNEP1 en_US
dc.subject testosterone levels en_US
dc.title Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1111/and.12359
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.01

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