Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review

Gonzales Rengifo, Gustavo Francisco; Chaupis, D.

dc.contributor.author	Gonzales Rengifo, Gustavo Francisco
dc.contributor.author	Chaupis, D.
dc.date.accessioned	2019-02-06T14:59:05Z
dc.date.available	2019-02-06T14:59:05Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5511
dc.description.abstract	Populations living at high altitudes (HA), particularly in the Peruvian Central Andes, are characterised by presenting subjects with erythrocytosis and others with excessive erythrocytosis (EE)(Hb>21 g dl(-1) ). EE is associated with chronic mountain sickness (CMS), or lack of adaptation to HA. Testosterone is an erythropoietic hormone and it may play a role on EE at HA. The objective of the present review was to summarise findings on role of serum T levels on adaptation at HA and genes acting on this process. Men at HA without EE have higher androstenedione levels and low ratio androstenedione/testosterone than men with EE, suggesting low activity of 17beta-hydroxysteroid dehydrogenase (17beta-HSD), and this could be a mechanism of adaptation to HA. Higher conversion of dehydroepiandrosterone to testosterone in men with EE suggests nigher 17beta-HSD activity. Men with CMS at Peruvian Central Andes have two genes SENP1, and ANP32D with higher transcriptional response to hypoxia relative to those without. SUMO‐specific protease 1 (SENP1) is an erythropoiesis regulator, which is essential for the stability and activity of hypoxia‐inducible factor 1 (HIF‐1α) under hypoxia. SENP1 reverses the hormone‐augmented SUMOylation of androgen receptor (AR) increasing the transcription activity of AR.In conclusion, increased androgen activity is related with CMS.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Andrologia
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Humans	en_US
dc.subject	Male	en_US
dc.subject	chronic mountain sickness	en_US
dc.subject	Chronic Disease	en_US
dc.subject	South America	en_US
dc.subject	Polycythemia/blood	en_US
dc.subject	Adaptation, Physiological/genetics	en_US
dc.subject	Altitude Sickness/blood/genetics/physiopathology	en_US
dc.subject	Androgen receptor	en_US
dc.subject	Androgens/blood/genetics	en_US
dc.subject	como	en_US
dc.subject	haemoglobin	en_US
dc.subject	Receptors, Androgen/metabolism	en_US
dc.subject	SNEP1	en_US
dc.subject	testosterone levels	en_US
dc.title	Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.1111/and.12359
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn	1439-0272