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RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins

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dc.contributor.author Figueroa-Angulo, Elisa E.
dc.contributor.author Calla Choque, Jaeson Santos
dc.contributor.author Mancilla-Olea, Maria Inocente
dc.contributor.author Arroyo, Rossana
dc.date.accessioned 2019-02-06T14:59:05Z
dc.date.available 2019-02-06T14:59:05Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5515
dc.description.abstract Iron homeostasis is highly regulated in vertebrates through a regulatory system mediated by RNA-protein interactions between the iron regulatory proteins (IRPs) that interact with an iron responsive element (IRE) located in certain mRNAs, dubbed the IRE-IRP regulatory system. Trichomonas vaginalis, the causal agent of trichomoniasis, presents high iron dependency to regulate its growth, metabolism, and virulence properties. Although T. vaginalis lacks IRPs or proteins with aconitase activity, possesses gene expression mechanisms of iron regulation at the transcriptional and posttranscriptional levels. However, only one gene with iron regulation at the transcriptional level has been described. Recently, our research group described an iron posttranscriptional regulatory mechanism in the T. vaginalis tvcp4 and tvcp12 cysteine proteinase mRNAs. The tvcp4 and tvcp12 mRNAs have a stem-loop structure in the 5'-coding region or in the 3'-UTR, respectively that interacts with T. vaginalis multifunctional proteins HSP70, alpha-Actinin, and Actin under iron starvation condition, causing translation inhibition or mRNA stabilization similar to the previously characterized IRE-IRP system in eukaryotes. Herein, we summarize recent progress and shed some light on atypical RNA-binding proteins that may participate in the iron posttranscriptional regulation in T. vaginalis. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Biomolecules
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Animals en_US
dc.subject Actin en_US
dc.subject alpha-Actinin en_US
dc.subject HSP70 en_US
dc.subject IRE-IRP system en_US
dc.subject iron en_US
dc.subject Iron/metabolism en_US
dc.subject posttranscriptional regulation by iron en_US
dc.subject Protein Processing, Post-Translational en_US
dc.subject Protozoan Proteins/genetics/metabolism en_US
dc.subject Response Elements en_US
dc.subject RNA-binding protein en_US
dc.subject RNA-Binding Proteins/genetics/metabolism en_US
dc.subject Trichomonas Infections/metabolism/parasitology en_US
dc.subject Trichomonas vaginalis en_US
dc.subject Trichomonas vaginalis/genetics/metabolism en_US
dc.title RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.3390/biom5043354
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn 2218-273X

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