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A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis

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dc.contributor.author Alvarez, Carolina
dc.contributor.author Verdonck, Kristien
dc.contributor.author Tipismana, Martin
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2019-02-06T14:59:05Z
dc.date.available 2019-02-06T14:59:05Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5518
dc.description.abstract Human T-lymphotropic virus 1 (HTLV-1) is frequent in Peru; an estimated 1–2% of the Peruvian population carry this retrovirus. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic disabling disease that affects about 1% of the carriers of HTLV-1. It is not yet known why some HTLV-1-infected people develop HAM/TSP while others do not. In this case report, we present a family with an unusually high burden of HAM/TSP: 5 (the 2 parents and 3 of their children) of 7 HTLV-1 carriers developed the same disease. We describe the clinical presentation and discuss the clustering of disease against the current knowledge of the pathogenesis of HAM/TSP. Families such as this may hold the key to discovering which factors trigger the development of HAM/TSP. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries BMJ Case Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adolescent en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Child, Preschool en_US
dc.subject Middle Aged en_US
dc.subject Human T-lymphotropic virus 1 en_US
dc.subject Family Health en_US
dc.subject Paraparesis, Tropical Spastic/blood/diagnosis en_US
dc.title A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/bcr-2015-209619
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 1757-790X


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