Universidad Peruana Cayetano Heredia
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis
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| dc.contributor.author | Alvarez, Carolina | |
| dc.contributor.author | Verdonck, Kristien | |
| dc.contributor.author | Tipismana, Martin | |
| dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
| dc.date.accessioned | 2019-02-06T14:59:05Z | |
| dc.date.available | 2019-02-06T14:59:05Z | |
| dc.date.issued | 2015 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/5518 | |
| dc.description.abstract | Human T-lymphotropic virus 1 (HTLV-1) is frequent in Peru; an estimated 1–2% of the Peruvian population carry this retrovirus. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic disabling disease that affects about 1% of the carriers of HTLV-1. It is not yet known why some HTLV-1-infected people develop HAM/TSP while others do not. In this case report, we present a family with an unusually high burden of HAM/TSP: 5 (the 2 parents and 3 of their children) of 7 HTLV-1 carriers developed the same disease. We describe the clinical presentation and discuss the clustering of disease against the current knowledge of the pathogenesis of HAM/TSP. Families such as this may hold the key to discovering which factors trigger the development of HAM/TSP. | en_US |
| dc.language.iso | eng | |
| dc.publisher | BMJ Publishing Group | |
| dc.relation.ispartofseries | BMJ Case Reports | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Peru | en_US |
| dc.subject | Adolescent | en_US |
| dc.subject | Female | en_US |
| dc.subject | Humans | en_US |
| dc.subject | Male | en_US |
| dc.subject | Young Adult | en_US |
| dc.subject | Child, Preschool | en_US |
| dc.subject | Middle Aged | en_US |
| dc.subject | Human T-lymphotropic virus 1 | en_US |
| dc.subject | Family Health | en_US |
| dc.subject | Paraparesis, Tropical Spastic/blood/diagnosis | en_US |
| dc.title | A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1136/bcr-2015-209619 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.00 | |
| dc.relation.issn | 1757-790X |
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