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Challenges in the diagnosis and management of neonatal sepsis

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dc.contributor.author Zea-Vera, Alonso
dc.contributor.author Ochoa, Theresa J.
dc.date.accessioned 2019-02-06T14:59:06Z
dc.date.available 2019-02-06T14:59:06Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5534
dc.description.abstract Neonatal sepsis is the third leading cause of neonatal mortality and a major public health problem, especially in developing countries. Although recent medical advances have improved neonatal care, many challenges remain in the diagnosis and management of neonatal infections. The diagnosis of neonatal sepsis is complicated by the frequent presence of noninfectious conditions that resemble sepsis, especially in preterm infants, and by the absence of optimal diagnostic tests. Since neonatal sepsis is a high-risk disease, especially in preterm infants, clinicians are compelled to empirically administer antibiotics to infants with risk factors and/or signs of suspected sepsis. Unfortunately, both broad-spectrum antibiotics and prolonged treatment with empirical antibiotics are associated with adverse outcomes and increase antimicrobial resistance rates. Given the high incidence and mortality of sepsis in preterm infants and its long-term consequences on growth and development, efforts to reduce the rates of infection in this vulnerable population are one of the most important interventions in neonatal care. In this review, we discuss the most common questions and challenges in the diagnosis and management of neonatal sepsis, with a focus on developing countries. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof urn:issn:1465-3664
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Infant en_US
dc.subject Incidence en_US
dc.subject Infant, Newborn en_US
dc.subject Infant, Premature en_US
dc.subject Infant Mortality en_US
dc.subject Anti-Bacterial Agents/therapeutic use en_US
dc.subject Bacterial Infections/drug therapy/microbiology/prevention & control en_US
dc.subject Infant, Newborn, Diseases/epidemiology en_US
dc.subject Infant, Premature, Diseases/epidemiology en_US
dc.subject Sepsis/diagnosis/drug therapy/microbiology en_US
dc.title Challenges in the diagnosis and management of neonatal sepsis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1093/tropej/fmu079
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06

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