DSpace Repository

Disease Diagnosis from Immunoassays with Plate to Plate Variability: A Hierarchical Bayesian Approach

Show simple item record

dc.contributor.author Entine, Oliver A.
dc.contributor.author Small, Dylan S.
dc.contributor.author Jensen, Shane T.
dc.contributor.author Sanchez, Gerardo
dc.contributor.author Bastos, Milagros
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.contributor.author Levy, Michael Z.
dc.date.accessioned 2019-02-22T14:53:57Z
dc.date.available 2019-02-22T14:53:57Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/5581
dc.description.abstract The standard methods of diagnosing disease based on antibody microtiter plates are quite crude. Few methods create a rigorous underlying model for the antibody levels of populations consisting of a mixture of positive and negative subjects, and fewer make full use of the entirety of the available data for diagnoses. In this paper, we propose a Bayesian hierarchical model that provides a systematic way of pooling data across different plates, and accounts for the subtle sources of variations that occur in the optical densities of typical microtiter data. In addition to our Bayesian method having good frequentist properties, we find that our method outperforms one of the standard crude approaches (the “3 SD Rule”) under reasonable assumptions, and provides more accurate disease diagnoses in terms of both sensitivity and specificity. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Statistics in Biosciences
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Monte Carlo method en_US
dc.subject performance en_US
dc.subject sensitivity and specificity en_US
dc.subject immunoassay en_US
dc.subject receiver operating characteristic en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject health care planning en_US
dc.subject simulation en_US
dc.subject optical density en_US
dc.subject Bayesian learning en_US
dc.title Disease Diagnosis from Immunoassays with Plate to Plate Variability: A Hierarchical Bayesian Approach en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s12561-014-9113-5
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.01.03
dc.relation.issn 1867-1772


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics