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Molecular epidemiology of plasmodium falciparum malaria outbreak, Tumbes, Peru, 2010–2012

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dc.contributor.author Baldeviano, G.C.
dc.contributor.author Akinyi Okoth, S.
dc.contributor.author Arrospide, N.
dc.contributor.author Gonzalez, R.V.
dc.contributor.author Sánchez, J.F.
dc.contributor.author Macedo, S.
dc.contributor.author Conde, S.
dc.contributor.author Tapia, L.L.
dc.contributor.author Salas, C.
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Herrera, Y.
dc.contributor.author Edgel, K.A.
dc.contributor.author Udhayakumar, V.
dc.contributor.author Lescano Guevara, Andres Guillermo
dc.date.accessioned 2019-02-22T14:54:00Z
dc.date.available 2019-02-22T14:54:00Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5595
dc.description.abstract During 2010–2012, an outbreak of 210 cases of malaria occurred in Tumbes, in the northern coast of Peru, where no Plasmodium falciparum malaria case had been reported since 2006. To identify the source of the parasite causing this outbreak, we conducted a molecular epidemiology investigation. Microsatellite typing showed an identical genotype in all 54 available isolates. This genotype was also identical to that of parasites isolated in 2010 in the Loreto region of the Peruvian Amazon and closely related to clonet B, a parasite lineage previously reported in the Amazon during 1998–2000. These findings are consistent with travel history of index case-patients. DNA sequencing revealed mutations in the Pfdhfr, Pfdhps, Pfcrt, and Pfmdr1 loci, which are strongly associated with resistance to chloroquine and sulfadoxine/pyrimethamine, and deletion of the Pfhrp2 gene. These results highlight the need for timely molecular epidemiology investigations to trace the parasite source during malaria reintroduction events. en_US
dc.language.iso eng
dc.publisher Centers for Disease Control and Prevention
dc.relation.ispartofseries Emerging Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Humans en_US
dc.subject Genotype en_US
dc.subject Plasmodium falciparum en_US
dc.subject Disease Outbreaks en_US
dc.subject Geography en_US
dc.subject drug resistance en_US
dc.subject human en_US
dc.subject Article en_US
dc.subject major clinical study en_US
dc.subject Microsatellite Repeats en_US
dc.subject genotype en_US
dc.subject history en_US
dc.subject antibiotic resistance en_US
dc.subject epidemic en_US
dc.subject genetics en_US
dc.subject nonhuman en_US
dc.subject parasitology en_US
dc.subject microsatellite DNA en_US
dc.subject gene locus en_US
dc.subject Molecular Epidemiology en_US
dc.subject Alleles en_US
dc.subject Haplotypes en_US
dc.subject Drug Resistance en_US
dc.subject History, 21st Century en_US
dc.subject blood sampling en_US
dc.subject DNA sequence en_US
dc.subject haplotype en_US
dc.subject molecular epidemiology en_US
dc.subject polymerase chain reaction en_US
dc.subject drug effects en_US
dc.subject allele en_US
dc.subject DNA, Protozoan en_US
dc.subject protozoal DNA en_US
dc.subject malaria falciparum en_US
dc.subject Malaria, Falciparum en_US
dc.subject gene deletion en_US
dc.subject geography en_US
dc.subject antimalarial agent en_US
dc.subject protozoal protein en_US
dc.subject Protozoan Proteins en_US
dc.subject point mutation en_US
dc.subject chloroquine en_US
dc.subject Antimalarials en_US
dc.subject DNA isolation en_US
dc.subject epidemiological monitoring en_US
dc.subject Gene Deletion en_US
dc.subject pyrimethamine plus sulfadoxine en_US
dc.title Molecular epidemiology of plasmodium falciparum malaria outbreak, Tumbes, Peru, 2010–2012 en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3201/eid2105.141427
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1080-6059


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