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Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity

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dc.contributor.author Barrera Tomas, M.
dc.contributor.author Tomas Chota, G.E.
dc.contributor.author Sheen Cortavarria, Patricia
dc.contributor.author Fuentes Bonilla, P.
dc.contributor.author Inocente Camones, M.A.
dc.contributor.author Santiago Contreras, J.
dc.date.accessioned 2019-02-22T14:54:00Z
dc.date.available 2019-02-22T14:54:00Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/5597
dc.description.abstract Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively. en_US
dc.language.iso eng
dc.publisher Universidad Nacional de Colombia
dc.relation.ispartofseries Revista Colombiana de Química
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Evernia prunastri en_US
dc.subject MIC en_US
dc.subject TEMA en_US
dc.subject Condensation reaction en_US
dc.title Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.15446/rev.colomb.quim.v46n3.61980
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.00
dc.relation.issn 2357-3791


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