Universidad Peruana Cayetano Heredia
Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
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| dc.contributor.author | Barrera Tomas, M. | |
| dc.contributor.author | Tomas Chota, G.E. | |
| dc.contributor.author | Sheen Cortavarria, Patricia | |
| dc.contributor.author | Fuentes Bonilla, P. | |
| dc.contributor.author | Inocente Camones, M.A. | |
| dc.contributor.author | Santiago Contreras, J. | |
| dc.date.accessioned | 2019-02-22T14:54:00Z | |
| dc.date.available | 2019-02-22T14:54:00Z | |
| dc.date.issued | 2017 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/5597 | |
| dc.description.abstract | Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Universidad Nacional de Colombia | |
| dc.relation.ispartofseries | Revista Colombiana de Química | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Evernia prunastri | en_US |
| dc.subject | MIC | en_US |
| dc.subject | TEMA | en_US |
| dc.subject | Condensation reaction | en_US |
| dc.title | Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.15446/rev.colomb.quim.v46n3.61980 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.04.00 | |
| dc.relation.issn | 2357-3791 |
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