Universidad Peruana Cayetano Heredia

Neurocysticercosis in Bhutan: a cross-sectional study in people with epilepsy

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dc.contributor.author Brizzi, Kate
dc.contributor.author Pelden, Sonam
dc.contributor.author Tshokey, Tshokey
dc.contributor.author Nirola, Damber K.
dc.contributor.author Diamond, Megan B.
dc.contributor.author Klein, Joshua P.
dc.contributor.author Tshering, Lhab
dc.contributor.author Deki, Sonam
dc.contributor.author Nidup, Dechen
dc.contributor.author Bruno, Veronica
dc.contributor.author Dorny, Pierre
dc.contributor.author Hugo Garcia, Hector
dc.contributor.author Mateen, Farrah J.
dc.contributor.author Bhutan Epilepsy Project
dc.date.accessioned 2019-02-22T14:54:02Z
dc.date.available 2019-02-22T14:54:02Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5603
dc.description.abstract Background: We sought to provide an assessment of the burden of neurocysticercosis among people with epilepsy (PWE) in Bhutan and evaluate the yield of various tests for Taenia solium. Methods: PWE were enrolled at the National Referral Hospital in Thimphu (2014-2015). Serum was tested for anti-Taenia solium IgG using ELISA (Ab-ELISA), enzyme-linked immunoelectrotransfer blot (EITB), and parasite antigen. Results were compared to brain MRI. Participants were categorized as definite neurocysticercosis (MRI and EITB positive), probable neurocysticercosis (MRI or EITB positive), or without neurocysticercosis. Logistic regression models were constructed to explore clinicodemographic associations. Results: There were 12/205 (6%, 95% CI 2%, 9%) definite and 40/205 (20%, 95% CI 14%, 25%) probable neurocysticercosis cases. 25/205 (12%) with positive EITB did not have neurocysticercosis on MRI, and 15/205 (7%) participants with positive MRI had negative EITB. Participants with neurocysticercosis-suggestive lesions on MRI had an average of 1.2 cysts (parenchymal 26/27; nodular/calcified stage 21/27). In a multivariable analysis, present age (OR 1.05, 95% CI 1.01,1.09, p=0.025) was positively associated with (combined probable or definite) neurocysticercosis while mesial temporal sclerosis on MRI (OR 0.294, 95% CI 0.144, 0.598, p=0.001) was negatively associated. Conclusions: Neurocysticercosis was associated with 6-25% of epilepsy in a Bhutanese cohort. Combining EITB and MRI would aid the diagnosis of neurocysticercosis among PWE since no test identified all cases. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Transactions of the Royal Society of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Neurocysticercosis en_US
dc.subject Epilepsy en_US
dc.subject Seizure en_US
dc.subject Bhutan en_US
dc.subject Enzyme-linked immunoelectrotransfer blot en_US
dc.subject Magnetic resonance imaging en_US
dc.title Neurocysticercosis in Bhutan: a cross-sectional study in people with epilepsy en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/trstmh/trw066
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1878-3503


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