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pic gene of enteroaggregative Escherichia coli and its association with diarrhea in Peruvian children

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dc.contributor.author Durand Vara, David Percy
dc.contributor.author Contreras, Carmen A.
dc.contributor.author Mosquito, Susan
dc.contributor.author Ruíz, Joaquim
dc.contributor.author Cleary, Thomas G.
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.date.accessioned 2019-02-22T14:54:28Z
dc.date.available 2019-02-22T14:54:28Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5631
dc.description.abstract Enteroaggregative Escherichia coli (EAEC) causes acute and persistent diarrhea among children, HIV-infected patients, and travelers to developing countries. We have searched for 18 genes-encoding virulence factors associated with aggregative adherence, dispersion, biofilm, toxins, serine protease autotransporters of Enterobacteriaceae (SPATEs) and siderophores, analyzed in 172 well-characterized EAEC strains (aggR(+)) isolated from stool samples of 97 children with diarrhea and 75 healthy controls from a passive surveillance diarrhea cohort study in Peru. Eighty-one different genetic profiles were identified, 37 were found only associated with diarrhea and 25 with control samples. The most frequent genetic profile was aggC(+)aatA(+)aap(+)shf(+)fyuA(+), present in 19 strains, including diarrhea and controls. The profile set1A(+)set1B(+)pic(+) was associated with diarrhea (P < 0.05). Of all genes evaluated, the most frequent were aatA (CVD 342) present in 159 strains (92.4%) and fyuA in 157 (91.3%). When EAEC strains were analyzed as a single pathogen (excluding co-infections), only pic was associated with diarrhea (P < 0.05) and with prolonged diarrhea (diarrhea >= 7 days) (P < 0.05). In summary, this is the first report on the prevalence of a large set of EAEC virulence genes and its association with diarrhea in Peruvian children. More studies are needed to elucidate the exact role of each virulence factor. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Pathogens and Global Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject children en_US
dc.subject diarrhea en_US
dc.subject control en_US
dc.subject virulence genes en_US
dc.subject aggR gene en_US
dc.subject EAEC en_US
dc.title pic gene of enteroaggregative Escherichia coli and its association with diarrhea in Peruvian children en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/femspd/ftw054
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 2047-7732


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