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The Quality of Reporting of Measures of Precision in Animal Experiments in Implant Dentistry: A Methodological Study

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dc.contributor.author Faggion, Clovis Mariano
dc.contributor.author Aranda, Luisiana
dc.contributor.author Diaz Cavero, Karla Tatiana
dc.contributor.author Shih, Ming-Chieh
dc.contributor.author Tu, Yu-Kang
dc.contributor.author Alarcon Palacios, Marco Antonio
dc.date.accessioned 2019-02-22T14:54:28Z
dc.date.available 2019-02-22T14:54:28Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5636
dc.description.abstract Purpose: Information on precision of treatment-effect estimates is pivotal for understanding research findings. In animal experiments, which provide important information for supporting clinical trials in implant dentistry, inaccurate information may lead to biased clinical trials. The aim of this methodological study was to determine whether sample size calculation, standard errors, and confidence intervals for treatment-effect estimates are reported accurately in publications describing animal experiments in implant dentistry. Materials and Methods: MEDLINE (via PubMed), Scopus, and SciELO databases were searched to identify reports involving animal experiments with dental implants published from September 2010 to March 2015. Data from publications were extracted into a standardized form with nine items related to precision of treatment estimates and experiment characteristics. Data selection and extraction were performed independently and in duplicate, with disagreements resolved by discussion-based consensus. The chi-square and Fisher exact tests were used to assess differences in reporting according to study sponsorship type and impact factor of the journal of publication. Results: The sample comprised reports of 161 animal experiments. Sample size calculation was reported in five (2%) publications. P values and confidence intervals were reported in 152 (94%) and 13 (8%) of these publications, respectively. Standard errors were reported in 19 (12%) publications. Confidence intervals were better reported in publications describing industry-supported animal experiments (P =.03) and with a higher impact factor (P =.02). Conclusion: Information on precision of estimates is rarely reported in publications describing animal experiments in implant dentistry. This lack of information makes it difficult to evaluate whether the translation of animal research findings to clinical trials is adequate. en_US
dc.language.iso eng
dc.publisher Quintessence Publishing
dc.relation.ispartofseries International Journal of Oral and Maxillofacial Implants
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject animal experimentation en_US
dc.subject methods en_US
dc.subject confidence interval en_US
dc.subject sample size en_US
dc.subject precision en_US
dc.subject treatment effect en_US
dc.title The Quality of Reporting of Measures of Precision in Animal Experiments in Implant Dentistry: A Methodological Study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.11607/jomi.4619
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.relation.issn 1942-4434


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