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Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes

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dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.contributor.author Tapia Aguirre, Vilma Lucrecia
dc.date.accessioned 2019-02-22T14:54:29Z
dc.date.available 2019-02-22T14:54:29Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/5651
dc.description.abstract Background: Currently there are no studies on γ-glutamyltransferase (γGT) levels at high altitude or on the relationship between γGT, uric acid and several dysfunctions. The aim of the study was to determine the association between serum γGT and uric acid levels in subjects at high altitude with hemoglobin, glycemia, and lipidic, hepatic and kidney markers. Methods: The present study was performed in 487 subjects aged 30-75 years living at 4100 m of altitude. A venous blood sample was drawn from each subject to measure hemoglobin, glucose, and lipid levels and markers of liver and kidney function. Quartiles for serum γGT and uric acid were calculated and associated with different physiological variables. A p-value <0.05 was considered statistically significant. Results: Serum γGT values were higher in men (38.35± 2.54 IU/L) than in women (30.33±1.76 IU/L) (p<0.01). Similarly, serum uric acid levels were higher in men (5.78± 0.12 mg/dL) than in women (4.29±0.08 mg/dL; p<0.001). Serum γGT levels in the top quartile were associated with higher glycemia, overweight/obesity, increased levels of non-high-density lipoprotein (non-HDL) cholesterol, triglycerides, alanine aminotransferase, alkaline phosphatase, uric acid, creatinine, and hemoglobin. Levels of uric acid in the top quartile were associated with overweight/obesity, elevated non-HDL cholesterol, triglycerides, creatinine, γGT and hemoglobin. Higher arterial blood pressure was associated with high levels of uric acid but not with γGT levels. Conclusions: At high altitude, increased γGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease. en_US
dc.language.iso eng
dc.publisher De Gruyter
dc.relation.ispartofseries Journal of Basic and Clinical Physiology and Pharmacology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject hemoglobin en_US
dc.subject high altitude en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Altitude en_US
dc.subject hypertension en_US
dc.subject Obesity en_US
dc.subject Overweight en_US
dc.subject obesity en_US
dc.subject altitude en_US
dc.subject human en_US
dc.subject Hypertension en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject female en_US
dc.subject male en_US
dc.subject middle aged en_US
dc.subject Article en_US
dc.subject kidney disease en_US
dc.subject pathophysiology en_US
dc.subject blood en_US
dc.subject metabolism en_US
dc.subject biological marker en_US
dc.subject Hemoglobins en_US
dc.subject blood sampling en_US
dc.subject hyperglycemia en_US
dc.subject dyslipidemia en_US
dc.subject Dyslipidemias en_US
dc.subject high density lipoprotein cholesterol en_US
dc.subject triacylglycerol en_US
dc.subject cholesterol blood level en_US
dc.subject glucose en_US
dc.subject glucose blood level en_US
dc.subject triacylglycerol blood level en_US
dc.subject uric acid en_US
dc.subject uric acid blood level en_US
dc.subject hemoglobin blood level en_US
dc.subject creatinine en_US
dc.subject Hyperglycemia en_US
dc.subject creatinine blood level en_US
dc.subject kidney function en_US
dc.subject alanine aminotransferase en_US
dc.subject alanine aminotransferase blood level en_US
dc.subject alkaline phosphatase en_US
dc.subject alkaline phosphatase blood level en_US
dc.subject arterial blood pressure en_US
dc.subject arterial pressure en_US
dc.subject Biological Markers en_US
dc.subject gamma glutamyl transferase blood level en_US
dc.subject gamma glutamyltransferase en_US
dc.subject gamma-Glutamyltransferase en_US
dc.subject hyperuricemia en_US
dc.subject Kidney Diseases en_US
dc.subject liver function en_US
dc.subject Uric Acid en_US
dc.subject venous blood en_US
dc.subject γ-glutamyltransferase en_US
dc.title Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1515/jbcpp-2013-0162
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 2191-0286


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