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Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study

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dc.contributor.author Gonzales, I.
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Rodriguez, S.
dc.contributor.author Vargas, V.
dc.contributor.author Cjuno, A.
dc.contributor.author Smeeth, L.
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author Tsang, V.C.W.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2019-02-22T14:54:30Z
dc.date.available 2019-02-22T14:54:30Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5652
dc.description.abstract Objectives: To examine the prevalence of seizures, epilepsy and seropositivity to cysticercosis in rural villagers (cysticercosis-endemic setting), rural-to-urban migrants into a non-endemic urban shanty town and urban inhabitants of the same non-endemic shanty town. Methods: Three Peruvian populations (n = 985) originally recruited into a study about chronic diseases and migration were studied. These groups included rural inhabitants from an endemic region (n = 200), long-term rural-to-urban migrants (n = 589) and individuals living in the same urban setting (n = 196). Seizure disorders were detected by a survey, and a neurologist examined positive respondents. Serum samples from 981/985 individuals were processed for cysticercosis antibodies on immunoblot. Results: Epilepsy prevalence (per 1000 people) was 15.3 in the urban group, 35.6 in migrants and 25 in rural inhabitants. A gradient in cysticercosis antibody seroprevalence was observed: urban 2%, migrant 13.5% and rural group 18% (P < 0.05). A similarly increasing pattern of higher seroprevalence was observed among migrants by age at migration. In rural villagers, there was strong evidence of an association between positive serology and having seizures (P = 0.011) but such an association was not observed in long-term migrants or in urban residents. In the entire study population, compared with seronegative participants, those with strong antibody reactions (≥ 4 antibody bands) were more likely to have epilepsy (P < 0.001). Conclusions: It is not only international migration that affects cysticercosis endemicity; internal migration can also affect patterns of endemicity within an endemic country. The neurological consequences of cysticercosis infection likely outlast the antibody response for years after rural-to-urban migration. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Tropical Medicine and International Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Middle Aged en_US
dc.subject Animals en_US
dc.subject Population Dynamics en_US
dc.subject Rural Population en_US
dc.subject Prevalence en_US
dc.subject Transients and Migrants en_US
dc.subject Cysticercosis en_US
dc.subject Neurocysticercosis en_US
dc.subject Taenia solium en_US
dc.subject antibody en_US
dc.subject cysticercosis en_US
dc.subject neurocysticercosis en_US
dc.subject public health en_US
dc.subject Epilepsy en_US
dc.subject Seizures en_US
dc.subject epilepsy en_US
dc.subject human en_US
dc.subject Urban Population en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject cross-sectional study en_US
dc.subject female en_US
dc.subject male en_US
dc.subject middle aged en_US
dc.subject very elderly en_US
dc.subject young adult en_US
dc.subject health risk en_US
dc.subject Article en_US
dc.subject major clinical study en_US
dc.subject Migration en_US
dc.subject prevalence en_US
dc.subject immunology en_US
dc.subject migration en_US
dc.subject blood en_US
dc.subject serum en_US
dc.subject Peruvian en_US
dc.subject migrant en_US
dc.subject rural population en_US
dc.subject urban population en_US
dc.subject animal en_US
dc.subject complication en_US
dc.subject immunoassay en_US
dc.subject Seroepidemiologic Studies en_US
dc.subject population dynamics en_US
dc.subject rural area en_US
dc.subject parasite prevalence en_US
dc.subject urban area en_US
dc.subject seroprevalence en_US
dc.subject Antibodies en_US
dc.subject antigen antibody reaction en_US
dc.subject endemic species en_US
dc.subject neurologist en_US
dc.subject neurology en_US
dc.subject parasitic disease en_US
dc.subject resident population en_US
dc.subject rural-urban migration en_US
dc.title Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/tmi.12456
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1365-3156


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