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In vitro antiproliferative activity of palladium(II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

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dc.contributor.author Hernández, Wilfredo
dc.contributor.author Vaisberg Wollach, Abraham Jaime
dc.contributor.author Tobar, Mabel
dc.contributor.author Álvarez, Melisa
dc.contributor.author Manzur, Jorge
dc.contributor.author Echevarría, Yuri
dc.contributor.author Spodine, Evgenia
dc.date.accessioned 2019-02-22T14:54:31Z
dc.date.available 2019-02-22T14:54:31Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5661
dc.description.abstract This work reports the synthesis and characterization of palladium(u) complexes Pd(L-1)(2) (1), Pd(L-2)(2) (2), Pd(L-3)(2) (3) and Pd(L-4)(2) (4), where (LH)-H-1: 1-naphthaldehyde thiosemicarbazone; (LH)-H-2: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; (LH)-H-3: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; (LH)-H-4: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L-1)(2) has the most potent activity for all the studied cell tines (IC50 similar to 11 mu M), with the exception of H460. Pd(L-2)(2) is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L-4)(2) is the complex which exhibits the lowest activity against the same cell line (IC50 similar to 11 mu M), being ten times lower than that of Pd(L-1)(2). These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11-13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L-1)(2), Pd(L-3)(2) and Pd(L-4)(2) show antiproliferative activity against DU-145, while those with Pd(L-2)(2), Pd(L-3)(2) and Pd(L-4)(2) against HuTu80. en_US
dc.description.sponsorship Este trabajo fue financiado por CONCYTEC [número 3130418]. es_PE
dc.language.iso eng
dc.publisher Royal Society of Chemistry
dc.relation.ispartofseries New Journal of Chemistry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject In vitro en_US
dc.subject palladium(ii) thiosemicarbazone en_US
dc.subject chitosan coated magnetite nanoparticles en_US
dc.title In vitro antiproliferative activity of palladium(II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1039/c5nj02429c
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.00
dc.relation.issn 1369-9261


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