Universidad Peruana Cayetano Heredia
In vitro antiproliferative activity of palladium(II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles
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| dc.contributor.author | Hernández, Wilfredo | |
| dc.contributor.author | Vaisberg Wollach, Abraham Jaime | |
| dc.contributor.author | Tobar, Mabel | |
| dc.contributor.author | Álvarez, Melisa | |
| dc.contributor.author | Manzur, Jorge | |
| dc.contributor.author | Echevarría, Yuri | |
| dc.contributor.author | Spodine, Evgenia | |
| dc.date.accessioned | 2019-02-22T14:54:31Z | |
| dc.date.available | 2019-02-22T14:54:31Z | |
| dc.date.issued | 2016 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/5661 | |
| dc.description.abstract | This work reports the synthesis and characterization of palladium(u) complexes Pd(L-1)(2) (1), Pd(L-2)(2) (2), Pd(L-3)(2) (3) and Pd(L-4)(2) (4), where (LH)-H-1: 1-naphthaldehyde thiosemicarbazone; (LH)-H-2: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; (LH)-H-3: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; (LH)-H-4: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L-1)(2) has the most potent activity for all the studied cell tines (IC50 similar to 11 mu M), with the exception of H460. Pd(L-2)(2) is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L-4)(2) is the complex which exhibits the lowest activity against the same cell line (IC50 similar to 11 mu M), being ten times lower than that of Pd(L-1)(2). These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11-13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L-1)(2), Pd(L-3)(2) and Pd(L-4)(2) show antiproliferative activity against DU-145, while those with Pd(L-2)(2), Pd(L-3)(2) and Pd(L-4)(2) against HuTu80. | en_US |
| dc.description.sponsorship | Este trabajo fue financiado por CONCYTEC [número 3130418]. | es_PE |
| dc.language.iso | eng | |
| dc.publisher | Royal Society of Chemistry | |
| dc.relation.ispartofseries | New Journal of Chemistry | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | In vitro | en_US |
| dc.subject | palladium(ii) thiosemicarbazone | en_US |
| dc.subject | chitosan coated magnetite nanoparticles | en_US |
| dc.title | In vitro antiproliferative activity of palladium(II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1039/c5nj02429c | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.04.00 | |
| dc.relation.issn | 1369-9261 |
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