Purpose: To review the clinical experience, management and outcome of cervicofacial necrotizing fasciitis (CNF) in patients treated in our institution. Methods: A retrospective review of patients with CNF from two large health care institutions completed over a 10-year period. Results: Five patients with complete data were identified. CNF was polymicrobial in 4 and monomicrobial in one patient and occurred as a result of odontogenic infection in 3, trauma in 1, and was idiopathic in one patient. All patients were treated with extensive debridement, broad spectrum antibiotics, and reconstruction with flaps. There was one death. Conclusions: Early diagnosis and rapid aggressive debridement are key elements for reducing mortality and optimizing the cosmetic and functional outcome in patients with CNF.